- TWO CAULERPIN ANALOGUES AND A SESQUITERPENE FROM CAULERPA RACEMOSA
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The ethyl acetate extract of Caulerpa racemosa yielded two new red pigments which are caulerpin analogues.A new sesquiterpenoid present was identified as 10-keto-3,7,11-trimethyldodecanoic acid.Key Word Index - Caulerpa racemosa; marine green alga; red pi
- Anjaneyulu, A. S. R.,Prakash, C. V. S.,Mallavadhani, U. V.
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- Large-scale preparation process of caulerpin
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The invention belongs to the technical field of organic chemical synthesis, and particularly relates to a large-scale preparation process of caulerpin. On the basis of an original three-step method (patent CN108484611B), the first step and the third step are greatly simplified, the complex process of the method is improved, and a large number of reaction intermediates can be rapidly obtained through rapid preparative liquid chromatography; therefore, a large number of target products, namely caulerpin, are obtained by constructing an amino acid-ionic liquid phase transfer catalysis system and extracting with a mixed solvent for the first time. Compared with an existing caulerpin synthesis method, the synthesis process is simpler and mature, the raw material cost is lower, the condition is mild, basically no by-product is generated, the yield and the actual yield are higher, gram-level large-scale mass production can be achieved, the method is suitable for industrial large-scale production, and extremely high medical value and wide market prospects are achieved.
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Paragraph 0044-0046; 0053-0055; 0056-0057; 0066-0068
(2022/01/10)
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- Simple synthesis method of caulerpin
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The invention belongs to the field of organic chemical synthesis, and discloses a simple synthesis method of caulerpin. The method includes the steps of firstly, using indole as the raw material without protecting amidogen on the indole, and conducting affinity substitution of methyl acetate on a second site of the indole to generate indole-2-methyl acetate; secondly, conducting a formylation reaction on a third site of the indole-2-methyl acetate to obtain 3-formyl-2-indole methyl acetate; finally, conducting between-two-molecule cyclization on the 3-formyl-2-indole methyl acetate to obtain the caulerpin. Compared with the prior art, the method is simple in process, low in raw material cost, mild in reaction condition, beneficial for industrialization, quite high in medical value and widein market prospect, and the synthesis cycle is greatly shortened.
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Paragraph 0045; 0050
(2018/09/21)
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- Method for simply and efficiently synthesizing caulerpin
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The invention belongs to the field of organic chemical synthesis and discloses a method for simply and efficiently synthesizing caulerpin. The method comprises the following steps: by taking 2-indolone as a raw material, firstly, performing halogenated acylation on the 2-indolone, protecting amino on indole, performing nucleophilic substitution at a site 2 of the amino, connecting malonic acid dimethyl, further performing decarboxylation and protection group removal so as to obtain 3-formyl-2-indole methyl acetate, and finally performing cyclization between two molecules, so as to obtain caulerpin. Compared with a disclosed method for synthesizing caulerpin, the method disclosed by the invention is simple in synthesis process, low in raw material cost, gentle in reaction condition, high inproduct purity, high in yield and easy in industrialization, and has a very high medical value and a wide market prospect.
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Paragraph 0043; 0048
(2018/07/30)
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