- TERTIARY AMINES, MEDICAMENTS CONTAINING SAID AMINES, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF
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The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.
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Paragraph 0547
(2013/12/04)
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- SYNTHESIS OF QUINOLINE 5-CARBOXAMIDES USEFUL FOR THE PREPARATION OF PDE IV INHIBITORS
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In one embodiment, the present application discloses a process for making the compound of the formula:
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Page/Page column 25
(2010/02/11)
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- Synthesis and profile of SCH351591, a novel PDE4 inhibitor
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The syntheses and pharmacological profiles of some 2-trifluoromethyl-8-methoxyquinoline-5-carboxamides are described. SCH351591 is a potent selective inhibitor of phosphodiesterase type 4 (PDE4).
- Billah, Motasim,Cooper, Nicola,Cuss, Francis,Davenport, Richard J.,Dyke, Hazel J.,Egan, Robert,Ganguly, Ashit,Gowers, Lewis,Hannah, Duncan R.,Haughan, Alan F.,Kendall, Hannah J.,Lowe, Christopher,Minnicozzi, Michael,Montana, John G.,Naylor, Robert,Oxford, Janet,Peake, Joanna C.,Piwinski, John J.,Runcie, Karen A.,Sabin, Verity,Sharpe, Andrew,Shih, Neng-Yang,Warneck, Julie B.H.
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p. 1621 - 1623
(2007/10/03)
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- Heterocyclic compounds and their therapeutic use
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N-oxides of formula (i) wherein R1is CH3, CH2F, CHF2or CF3; R2is CH3or CF3; R3is F, Cl, Br, CN or CH3; and R4is H, F, Cl, Br, CN or CH3; and pharmaceutically-acceptable salts thereof, are useful as therapeutic agents, e.g. for the treatment of inflammatory diseases.
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