- Preparation method of 3-isothiazolinone compound
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The invention discloses a preparation method of a 3-isothiazolinone compound, which comprises the following steps of adding raw materials and a solvent into a reaction system, and stirring and mixing,adding a dehydrating agent into the mixed solution, and stirring for reaction, introducing chlorine into the reaction system, stirring the reaction mixture for reaction, filtering and separating to obtain a product. According to the method, the chemical dehydrating agent is added into the reaction system to react with water or alcohol in the reaction system, so that water or alcohol in the systemis removed, side reaction caused by water or alcohol is avoided, the reaction yield is increased, and the economic benefit is remarkable.
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Paragraph 0030-0032; 0036-0039
(2020/12/31)
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- Preparation method of 2-methyl-4-isothiazoline-3-one aqueous solution
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The invention provides a preparation method of a 2-methyl-4-isothiazoline-3-one aqueous solution. The method comprises the following concrete steps: uniformly mixing N,N'-dimethyl-3,3'-dithiodipropionamide or N-methyl-3-mercaptopropionamide with a solvent; adding a halogenating agent into the mixed solution, and carrying out a halogenation ring closing reaction; filtering to obtain a product, washing a filter cake with ethyl acetate, and drying to obtain a 2-methyl-4-isothiazoline-3-one hydrochloride solid; and dissolving the 2-methyl-4-isothiazoline-3-one hydrochloride solid by using a sodiumcarbonate aqueous solution to obtain an aqueous solution of which the pH value is 5.0-7.0 and the mass fraction of 2-methyl-4-isothiazoline-3-one is 50%. According to the invention, the purity of the2-methyl-4-isothiazoline-3-one obtained by the method reaches 99.9% or above, and the content of 5-chlorine-2-methyl-4-isothiazoline-3-one can be controlled to be 100 ppm or below.
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Paragraph 0045-0047
(2020/12/31)
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- Pipeline type continuous production method of 3-isothiazolinone compound
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The invention discloses a pipeline type continuous production method of a 3-isothiazolinone compound, which comprises the following steps: carrying out mixed reaction on a thioamide compound, a catalyst, a solvent and chlorine through a pipeline reactor system, and carrying out after-treatment after the reaction is completed to obtain the 3-isothiazolinone compound. According to the method, the defects of large occupied area, small productivity, low efficiency, high energy consumption and small safety coefficient caused by existing batch production of the 3-isothiazolinone compound are overcome; the invention provides a mode for continuously producing the 3-isothiazolinone compound, so that the reaction process is easy to control, energy consumption is reduced, the production efficiency and the safety coefficient of the production process are improved, and the process is an efficient and energy-saving safe production process.
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Paragraph 0017
(2019/12/02)
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- Preparation method of high-purity 2-alkyl-4-isothiazoline-3-ketone
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The invention discloses a preparation method of high-purity 2-alkyl-4-isothiazoline-3-ketone. The preparation method comprises the following steps: suspending amide into a reaction medium inert solvent; introducing CMI and MIT mixture tail gas or MIT tail gas generated by the previous step, so as to obtain an amide suspending solution with proper hydrogen chloride content; and introducing a chlorinating reagent. According to the preparation method, a byproduct, namely hydrogen chloride, has an inhibition effect on the generation of 5-chloro-2-alkyl-4-isothiazoline-3-ketone. The content of the hydrogen chloride is increased through utilizing reaction raw materials and solvents; and finally, the high-purity 2-alkyl-4-isothiazoline-3-ketone is obtained.
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Paragraph 0037; 0038; 0039; 0040
(2017/07/19)
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- A preparation N-methyl thiazoline-2-ketone compound by the method
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The invention discloses a method for preparing an N-Methylthiazoline-2-ketone compound. In an inert atmosphere, an organic solvent is taken as a reaction medium, copper salt and an antioxidant are taken as a catalytic system, and a thiazole compound is oxidized into the N-Methylthiazoline-2-ketone compound through an oxidative methylation reaction. The preparation method disclosed by the invention is higher in reactivity, mild in reaction conditions, short in reaction time and high in yield; used catalysts are low in price and toxicity, and less in use amount, a multi-step reaction is shortened to a one-step reaction, and the treatment is simple, thereby being beneficial to purifying products; most importantly, the use of a toxic and volatile methylation reagent is avoided. The catalyst system disclosed by the invention has universality for a variety of reactants. Raw materials of the invention are readily available, and the reaction process is simple and controllable, so that the method is suitable for the industrialized production.
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Paragraph 0037-0039
(2017/04/03)
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- STABLE COMPOSITIONS OF THIABENDAZOLE AND IODINE-CONTAINING FUNGICIDES
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The present invention relates to stable compositions for the fungicidal equipment of thermoplastic polymers, in particular PVC, comprising thiabendazole, at least one iodine-containing fungicide and at least one epoxide and optionally further fungicidally active compounds, and also to methods for preparing these formulations and to uses thereof for the protection of thermoplastic polymers against attack and destruction by microorganisms. Moreover, the invention relates to mold-resistant PVC materials equipped with the compositions according to the invention.
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- FUNGICIDAL PENFLUFEN MIXTURES
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The invention relates to mixtures comprising penflufen, to the use of these mixtures for protecting industrial materials and to a method for treating industrial materials with the penflufen mixtures.
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- Synergistic biocidal composition
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The invention relates to a biocidal composition which can be added to materials which can be attacked by harmful micro-organisms, containing pyrithione as a biocidal active ingredient. The biocidal composition is characterised in that it contains 2-alkyl isothiazoline-3-one as another biocidally active ingredient. The active ingredients of the biocidal composition behave synergistically and are ideally suitable for controlling bacteria, fungus and algae.
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- Bromonitrothienyldioxanes
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The invention relates to novel 5-bromo-5-nitro-2-thienyl-1,3-dioxanes of the formula (I) in which R1, R2 and R3 are as defined in the description are highly suitable for use as biocides for protecting plants and industrial materials.
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- 3-NITROISOXAZOLES AND THEIR USE IN THE PROTECTION OF MATERIALS
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The 3-nitroisoxazoles of the formula (I) in which R1 and R2 are each as defined in the description, some of which are known, are highly suitable for use as biocides for protecting industrial materials.
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- Thiazines and thiazoles as agents for protecting materials
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The novel and known thiazines and thiazoles of the formula (I) in which R1, R2 and n are as defined in the description, are highly suitable for use as biocides for protecting industrial materials.
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- O-aryl dithiazole dioxides
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The invention relates to new O-aryldithiazole dioxides, to two processes for their preparation, and to their use as pesticides in crop protection and in the protection of materials.
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- Isothiazoles. Part 14: New 3-aminosubstituted isothiazole dioxides and their mono- and dihalogeno derivatives
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3-Alkylamino- and 3-arylamino isothiazole dioxides unsubstituted at C-4 and C-5 were synthesized starting from dithiopropionic amides. Taking advantage of the direct chlorination during the cyclization process or realizing an addition-elimination process with bromine on the final 3-aminoisothiazole dioxide derivatives, the corresponding 5-chloro-, 4,5-dichloro- or the 4-bromoisothiazole dioxides could also be made available.
- Clerici, Francesca,Contini, Alessandro,Gelmi, Maria Luisa,Pocar, Donato
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p. 9399 - 9408
(2007/10/03)
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- Method for producing 2-alkyl-4-isothiazoline-3-one
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Chlorinating agent is reacted with a compound represented by formula (I) (wherein R represents C1 to C8 alkyl groups or aralkyl groups) or a compound represented by formula (II) in a solvent in which hydrogen chloride is insoluble or has low solubility, to prepare 2-alkyl-4-isothiazoline-3-ones represented by general formula (III)
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- Agents for preserving technical materials against insects
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The use of the compounds of the formula (I) as agents for preserving technical materials against insects.
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- Wood preservatives
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Wood preservatives having biocidal properties which include quaternary ammonium compounds of general formula (I): wherein R1 is a C8-18-alkyl group or an optionally substituted benzyl group, R2 is a C8-18-alkyl group, R3 is a C1-4-alkyl group or a group of the formula —[CH2—CH2—O]n—H, R4 is a C1-4-alkyl group, n is a number from 0.5 to 8, preferably from 1 to 5, and A?is the anion of an organic carboxylic acid which contains 2 to 12 C atoms and carries at least one hydroxyl, amino or sulfonic acid group. The wood preservatives also penetrate deeply into the wood without the use of pressure, and have only a mild corrosive action on metals. Furthermore, a process for treating timbers with these compositions, concentrates for the preparation thereof, the use of new and known quaternary ammonium compounds in wood preservatives and new quaternary ammonium compounds and their use as biocides.
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- Dithiazoldioxides and the use thereof as microbicides
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The invention relates to novel dithiazole dioxides, to processes for their preparation and to their use in crop protection and in the protection of materials.
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- Arylthio-dithiazindioxides and their use as pesticides
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PCT No. PCT/EP97/07242 Sec. 371 Date Jun. 23, 1999 Sec. 102(e) Date Jun. 23, 1999 PCT Filed Dec. 22, 1997 PCT Pub. No. WO98/29400 PCT Pub. Date Jul. 9, 1998The invention relates to novel S-aryl-dithiazine dioxides, to processes for their preparation and to the use in crop protection and in the protection of materials.
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- N-sulfonyliminodithio compounds useful for in plant and material protection
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N-sulfonyliminodithio compounds have the formula (I), in which R1 and R2 stand for optionally substituted alkyl, alkenyl or alkinyl, and Ar stands for optionally substituted aryl; also disclosed are processes for preparing these compounds and their use for plant and material protection. STR1
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- 1,3,2-benzodithiazol-1-oxides as microbiocides
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A description is given of novel and know 1,3,2-benzodithiazole 1-oxides of the formula (I) STR1 and of their preparation and use for protecting industrial materials against infestation by microorganisms.
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- Mould-resistant emulsion paints
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The application relates to emulsion paints which are protected against fungal infestation by the use of N-alkyl-benzothiophene-2-carboxamide S,S-dioxides.
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- Thiazolylpyrazolinones and their use for protecting technical materials
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The present invention relates to novel thiazolylpyrazolinones, a process for their preparation and their use for the protection of technical materials.
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- Medicaments containing 1-thiocarbamoyl-5-hydroxy-pyrazoles and their use as agents for combating septic shock
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This application relates to new thiocarbamoyl compounds of the formula (I) STR1 in which R1, R2, R3 and R4 have the meanings given in the description.
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- Termite-controlling agent composition
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Combating termites with a composition comprising (a) at least one compound of the formula STR1 wherein, R denotes a hydrogen atom, acyl, alkyl or optionally substituted heteroarylalkyl, A denotes a hydrogen atom, alkyl or a bivalent group which binds to B, D denotes alkyl, --S--R1, STR2 or bivalent group or atom which binds to A. wherein R1 or R2 each independently denotes a hydrogen atom, acyl, alkyl or optionally substituted heteroarylalkyl. Y denotes =N-- or STR3 wherein T1 denotes a hydrogen atom or optionally substituted alkyl, and X denotes an electron attracting group, and (b) a pyrethoid compound.
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- Low-temperature-stabilized isothiazolinone concentrates
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A liquid concentrate comprises between about 4 and about 25 wt % of an isothiazolinone compound or mixture of isothiazolinone compounds between about 25 and about 88 wt % of a plasticizer in which said isothiazolinone compound is soluble and between about 8 and about 50 wt % of a C6 -C12 monoalkylphenol(s) which stabilizes the concentrate against crystallization and/or freezing at sub-freezing conditions.
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- Liquid isothiazolinone concentrates having improved low temperature-stability and improved anti-bacterial properties
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A liquid concentrate comprises between about 4 and about 10 wt % of an isothiazolinone compound or mixture of isothiazolinone compounds, between about 25 and about 92 wt % of a plasticizer in which said isothiazolinone compound is soluble and between about 4 and about 50 wt % of 2,4,4'-trichloro-2'-hydroxydiphenyl ether. The 2,4,4'-trichloro-2'-hydroxydiphenyl ether stabilizes the concentrate against crystallization and/or freezing at sub-freezing conditions, particularly when the isothiazolinone compound has a melting point of 30° C. or above. 2,4,4'-trichloro-2'-hydroxydiphenyl ether also enhances the anti-microbial properties of an isothiazolinone-containing concentrate.
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- Agents for preserving technical materials against insects
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Agents for preserving technical materials against insects, characterized in that they contain at least one compound of the formula (I) wherein Z represents 2-chloro-5-pyridiyl or 2-chloro-5-thiazolyl, and, R1 and R2 each independently represents hydrogen or C 1 4 alkyl.
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- A General Synthesis of N-Substituted Isothiazol-3(2H)-ones
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A general route to the synthesis of N-substituted isothiazol-3(2H)-ones (4a-i) is described which proceeds via trichloroacetic acid-mediated ring closure of N-substituted (Z)-3-(benzylsulfinyl)propenamides (15a-i).
- Beeley, Nigel R. A.,Harwood, Laurence M.,Hedger, Paul C.
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p. 2245 - 2252
(2007/10/02)
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- SYNTHESIS OF 2-SUBSTITUTED 3(2H)-ISOTHIAZOLONES FROM 2-SUBSTITUTED 5-AROYL-3(2H)-ISOTHIAZOLONES
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2-Substituted 3(2H)-isothiazolones 3 have been prepared from 2-substituted 5-aroyl-3(2H)-isothiazolones 6, which are readily available from N-substituted 3-aroylpropionamides 5.The nucleophilic displacement on the 5-aroyl group was found to proceed easily and quantitatively when a benzene solution of compound 6 was stirred at room temperature either with 10percent sodium hydroxide solution or with solid sodium hydroxide.
- Tsolomitis, Athanase,Sandris, Constantine
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p. 569 - 575
(2007/10/02)
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- SYNTHESES OF β-LACTAMS BY RING CONTRACTION OF ISOTHIAZOLIDINONES
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Several methods have been developed for the preparation of β-lactams from isothiazolidinones.Oxidation of 2-t-butyl-4,4-diphenyl- and 2,4,4-trimethyl-isothiazolidin-3-ones (4a) and (4b) with sulphuryl chloride afforded the 5-chloroisothiazolidinones (5a) and (5b), which were converted into 1-t-butyl-3,3-diphenyl- nd 1,3,3-trimethyl-4-phenylthioazetidin-2-ones (6a) and (6b) by treatment with phenyl-lithium.Alternatively, reaction of the isothiazolidinones (4a) and (4b) with phenyl-lithium gave N-t-butyl-2,2-diphenyl- and N,2,2-trimethyl-3-phenylthiopropionamides(12a) and (12b), which were transformed into the β-lactams (6a) and (6b) by halogenation at C-3, followed by treatment with potassium amide.These are examples of methods used to prepare β-lactams from isothiazolidinones.The verstility of these reactions and their relevance to penicilin biosynthesis is discussed.
- Easton, Christopher J.
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p. 153 - 158
(2007/10/02)
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- 3-Alkoxy-2-alkylisothiazolium salts and their derivatives
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This disclosure relates to a novel class of 3-alkoxy-2-alkylisothiazolium salts. These salts have been found to be useful in controlling the growth of bacteria and fungi. They have also been found to be useful intermediates in the preparation of known antibacterial and antifungal compounds.
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- 2-Alkyl-3-haloisothiazolium salts and their derivatives
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This disclosure relates to a novel class of 2-alkyl-3-haloisothiazolium salts. These salts have been found to be useful in controlling the growth of bacteria and fungi. They have also been found to be useful intermediates in the preparation of novel and known antibacterial and antifungal compounds.
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