268544-50-9

Basic information

• Product Name: 2-[(2-Methoxy-2-oxoethoxy)imino]-3-oxobutanoic acid 1,1-dimethylethyl ester
• Synonyms: 2-(Methoxycarbonylmethoxyimino)-3-oxobutyric acid tert-butyl ester;2-[(2-Methoxy-2-oxoethoxy)imino]-3-oxobutanoic acid 1,1-dimethylethyl ester;Butanoic acid, 2-[(2-Methoxy-2-oxoethoxy)iMino]-3-oxo-, 1,1-diMethylethyl ester
• CAS NO: 268544-50-9
• Molecular Formula: C11H17NO6
• Molecular Weight: 259.26
• Mol File: 268544-50-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[(2-Methoxy-2-oxoethoxy)imino]-3-oxobutanoic acid 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-Methoxy-2-oxoethoxy)imino]-3-oxobutanoic acid 1,1-dimethylethyl ester(268544-50-9)
• EPA Substance Registry System: 2-[(2-Methoxy-2-oxoethoxy)imino]-3-oxobutanoic acid 1,1-dimethylethyl ester(268544-50-9)

Safety Data

• Hazardous Substances Data: 268544-50-9(Hazardous Substances Data)

Upstream product

• 79232-64-7 (Z)-2-hydroxyimino-3-oxo-butyric acid tert-butyl ester 
• 96-34-4 methyl chloroacetate 
• 1694-31-1 tert-butyl acetoacetate 
• 14352-65-9 t-butyl 2-hydroxyimino-3-oxobutanoate 

Downstream Products

• 95759-10-7 4-chloro-2-[(methoxycarbonyl)methoxyimino]-3-oxo-butyric acid 

Relevant articles and documents

A method for producing the active MICA environmental protection (by machine translation)

A active MICA environment-friendly production method, comprises the following steps: oximation, alkylation, chlorinated, ring, process for preparing the intermediate. The invention realizes the recycled, thereby reducing the cost, reduces the amount of waste and waste water; will be S1 in the recrystallization of the sodium acetate as by-product, for S4 in the ring, reducing the waste water and its salt content; in S2 in, now process generally utilizes a potassium carbonate to provide alkaline environment, general in the consumption of 2 more than one equivalent, shortcomings are as follows: a, in the salt in the reaction process too big stirring strenous, b, post-processing needs a large amount of water dissolved inorganic salt, form a large amount of high salt waste water, is changed into the organic base after the solid salt in the reaction process is greatly reduced, post-processing of organic base recycling, reducing the cost and amount of waste water; S3 using batch feeding mode, can be reduced under the same conversion rate, the amount of sulfonyl chloride; S5 recycling reaction generated by-product 2 - mercaptobenzothiazole, recycled in the synthesis of disulphide diphenyl thiazole. (by machine translation)

Synthesis of (Z)-2-(2-formamido-4-thiazolyl)-2-(substituted alkoxyimino) acetic acids

(Z)-2-(2-formamido-4-thiazolyl)-2-(substituted alkoxyimino) acetic acids were synthesized by a new method based on the following sequence of reactions: treatment of the tert-butyl acetoacetate with sodium nitrite, alkylation of the oxime formed with an appropriate alkyl halide, halogenation of methyl α-keto group and simultaneous cleavage of tert-butyl ester with sulfuryl chloride, protection of the obtained acid function with diphenyldiazomethane, formation of the 2-aminothiazole ring by the Hantzsch method with thiourea, formylation of the amino group and selective final cleavage of the diphenylmethyl ester by treatment with trifluoroacetic acid and anisol. The developed procedure allows the synthesis of (Z)-2-(2- formamido-4-thiazolyl)-2-(substituted alkoxyimino) acetic acids, with an ester function in the alkoxyimino group employing a simple method and obtaining higher yields in comparison with the habitually used classic method. (C) 2000 Elsevier Science S.A.

3-Phosphonium and 3-phosphoranylidenecephems

This invention relates to novel 7-acylamino-3-vinylcephalosporanic acid derivatives of high antimicrobial activity, to processes for preparation thereof from novel intermediates, and to said intermediates of the formula: STR1 in which RA is a group of the formula: STR2 wherein R1 is amino-substituted-heterocyclic group which may have halogen, protected amino-substituted-heterocyclic group which may have halogen, or a group of the formula: STR3 wherein R3 is lower alkyl, R8 is aryl, A is lower alkylene which may have a substituent selected from the group consisting of amino, a protected amino group, hydroxy, oxo and a group of the formula: wherein R4 is hydrogen, cyclo(lower)alkenyl, lower alkynyl, lower alkenyl, lower alkenyl substituted by carboxy or a protected carboxy group, lower alkyl, or lower alkyl substituted by one or more substituent(s) selected from carboxy, a protected carboxy group, amino, a protected amino group, cyano, phosphono, a protected phosphono group and a heterocyclic group which may have suitable substituent(s), Ra is a protected amino group, Rb is a protected carboxy group, RB is a group of the formula: wherein R7 is aryl, and X2 and X3 are each halogen, and R2 is carboxy or a protected carboxy group, provided that, when RA is a group of the formula: R8 --CH=N--, wherein R8 is as defined above, then RB is a group of the formula: wherein R7 and X3 are each as defined above, or a salt thereof.