268547-52-0Relevant articles and documents
CRF RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO
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Page/Page column 23, (2008/06/13)
CRF receptor antagonists are disclosed which may have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a mammals, such as stroke. The CRF receptor antagonists of this invention have the following structure: and pharmaceutically acceptable salts, esters, solvates, stereoisomers and prodrugs thereof, wherein R1, R2n, R5, Ar, and Het are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.
Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists
Gross, Raymond S.,Guo, Zhiqiang,Dyck, Brian,Coon, Tim,Huang, Charles Q.,Lowe, Richard F.,Marinkovic, Dragan,Moorjani, Manisha,Nelson, Jodene,Zamani-Kord, Said,Grigoriadis, Dimitri E.,Hoare, Sam R. J.,Crowe, Paul D.,Bu, Jane Han,Haddach, Mustapha,McCarthy, James,Saunders, John,Sullivan, Robert,Chen, TaKung,Williams, John P.
, p. 5780 - 5793 (2007/10/03)
Antagonists of the corticotropin-releasing factor (CRF) neuropeptide should prove to be effective in treating stress and anxiety-related disorders. In an effort to identify antagonists with improved physicochemical properties, new tricyclic CRF1/sub
CRF receptor antagonists and methods relating thereto
-
, (2008/06/13)
CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have the following structure: including stereoisomers and pharmaceutically acceptable salts thereof, wherein n, m, A, B, C, R, R1, R2and Ar are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same
CRF receptor antagonists and methods relating thereto
-
, (2008/06/13)
CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have the following structure: including stereoisomers and pharmaceutically acceptable salts thereof, wherein n, m, A, B, C, R, R1, R2and Ar are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same