- Enzymatic desymmetrization of meso-2,3-bis(acetoxymethyl) and bis(hydroxymethyl) substituted hexachloronorbornadiene derivatives
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meso-Bis(acetoxymethyl)-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hepta-2, 5-diene and meso-bis(hydroxymethyl)-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hepta-2, 5-diene were transformed into chiral monoesters with 65-92% ee via enzymatic desymmetrization using various lipases. The absolute configuration was determined by transforming 2-acetoxymethyl-3-hydroxymethyl-1,4,5,6,7,7- hexachlorobicyclo[2.2.1]hepta-2,5-diene into the 2-acetoxymethyl-3- hydroxymethylbicyclo[2.2.1]hepta-2,5-diene of known absolute configuration.
- Tanyeli, Cihangir,Karadag, Timur,Akhmedov, Idris Mecitoglu
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