Identification of antitumor activity of pyrazole oxime ethers
A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15.
Park, Hyun-Ja,Lee, Kyung,Park, Su-Jin,Ahn, Bangle,Lee, Jong-Cheol,Cho, HeeYeong,Lee, Kee-In
p. 3307 - 3312
(2007/10/03)
Introduction of N-containing heterocycles into pyrazole by nucleophilic aromatic substitution
The nucleophilic aromatic substitution on 5-chloropyrazoles activated by the electron-withdrawing formyl group offers a useful method to introduce a wide range of N-containing heterocycles into them. The rate of reaction was greatly affected by the electronic nature of the N-1 substitution.
Park, Min-Sup,Park, Hyun-Ja,Park, Koon Ha,Lee, Kee-In
p. 1541 - 1550
(2007/10/03)
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