270065-74-2 Usage
Uses
Used in Pharmaceutical Industry:
Boc-(S)-3-Amino-4-(2-trifluoromethyl-phenyl)-butyric acid is utilized as a key intermediate in the synthesis of peptidomimetic drugs and peptides, contributing to the development of novel therapeutic agents that mimic the action of peptides but offer enhanced stability and bioavailability.
Used in Biochemical Research:
In the field of biochemical research, Boc-(S)-3-Amino-4-(2-trifluoromethyl-phenyl)-butyric acid serves as a valuable tool for studying enzyme-substrate interactions and protein-ligand binding. Its unique structure allows for the exploration of molecular recognition processes and the design of inhibitors or activators for specific biological targets.
Check Digit Verification of cas no
The CAS Registry Mumber 270065-74-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,0,0,6 and 5 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 270065-74:
(8*2)+(7*7)+(6*0)+(5*0)+(4*6)+(3*5)+(2*7)+(1*4)=122
122 % 10 = 2
So 270065-74-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H20F3NO4/c1-15(2,3)24-14(23)20-11(9-13(21)22)8-10-6-4-5-7-12(10)16(17,18)19/h4-7,11H,8-9H2,1-3H3,(H,20,23)(H,21,22)/t11-/m0/s1
270065-74-2Relevant articles and documents
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
