- Preparation of 2-amino-4-fluoropyrimidine derivatives
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A process for the preparation of 2-amino-4-fluoropyrimidine derivatives of the general formula I STR1 (R1 hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, phenyl or benzyl, it being possible for the aromatic rings to be substituted, and R2/
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- MECHANISMS FOR REACTIONS OF HALOGENATED COMPOUNDS. PART 6. INVESTIGATIONS INTO THE ACTIVATING EFFECT OF ORTHO-FLUORINE IN NUCLEOPHILIC AROMATIC SUBSTITUTION
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Separate activating effects for ortho- and meta- fluorine, on nucleophilic aromatic substitution, are determinated for pyrimidine and pyridine systems.Comparisons confirm the importance of ion-dipole interactions for activation by ortho-fluorine.The effects of ortho-fluorine on anionic ?-complexes are also discussed.
- Chambers, Richard D.,Seabury, Mark J.,Williams, D. Lyn H.,Hughes, Nigel
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p. 255 - 258
(2007/10/02)
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