A convenient scaleable process for the preparation of substituted phenylglycines 2 by a modified Strecker reaction is described. Bisulfite- mediated addition of benzylamine and cyanide anion to substituted benzaldehydes 3 gave the aminonitriles 4 which were hydrolysed in two steps to the N-protected amino acid 1. Debenzylation using catalytic transfer hydrogenation gave the title compounds in good yield.
Davies, Antony J.,Ashwood, Michael S.,Cottrell, Ian F.
p. 1095 - 1102
(2007/10/03)
More Articles about upstream products of 271583-50-7