7-alkyl- and cycloalkyl-substituted imidazotriazinones
The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.
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(2008/06/13)
Enhancement of the rectal absorption of sodium ampicillin by N-acylamino acids in rats
The promoting efficacies of N-acyl derivatives of amino acids on the rectal absorption of sodium ampicillin were investigated using the rat rectal loop technique. N-Acyl derivatives with longer carbon chains in the acyl moiety showed a greater promoting potency. The promoting potencies of N-acyl derivatives of phenylglycine and phenyl-alanine were greater than those of glycine and alanine derivatives when compared at the same length of carbon chain in their acyl moieties. The promoting action of N-acylamino acids was not influenced by the presence of N-ethylmaleimide or ouabain. The promoting potencies of N-acylamino acids were depressed in the presence of calcium chloride in the rectal loop. The contribution of the calcium ion sequestration capacity of N-acylamino acids to their promoting efficacies is discussed.
Wu,Murakami,Higashi,Yata
p. 508 - 512
(2007/10/02)
Inverse Phase Transfer Catalysis. First Report of a New Class of Interfacial Reactions
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Mathias, Lon J.,Vaidya, Rajeev A.
p. 1093 - 1094
(2007/10/02)
Melting Behaviour of Some Pure N-Acyl Amino Acids and Peptides
Fifty three tlc pure N-acyl amino acids were synthesized by Schotten-Baumann reaction from glc pure odd and even chain fatty acids and chromatographycally homogeneous amino acids and a few N-acyl peptides were prepared through the carboxylic carbonic anhydride intermediates.The melting points are reported and discussed.
Iyer, Venkataraman N.,Sheth, Geeta N.,Subrahmanyam, V. V. R.
p. 856 - 859
(2007/10/02)
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