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CAS

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27199-40-2

Pifexole is a synthetic chemical compound that belongs to the class of drugs known as dopamine agonists. It is primarily used for the treatment of Parkinson's disease and other neurological conditions by increasing the levels of dopamine in the brain. Pifexole works by stimulating the dopamine receptors, which helps to improve motor function and reduce the symptoms of tremors, rigidity, and slow movements associated with these conditions. It has also been studied for its potential use in the treatment of depression and other psychiatric disorders due to its effects on the brain's neurotransmitter system. Pifexole is typically administered orally and is generally well-tolerated, although it may cause side effects such as nausea, dizziness, and hallucinations in some individuals. It is important to use this medication under the guidance and supervision of a healthcare professional.

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  • 27199-40-2 Structure

  • Basic information

    1. Product Name: Pifexole
    2. Synonyms: Pifexole;4-[5-(o-Chlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine;RI-64;RJ-64;Udarnol
    3. CAS NO:27199-40-2
    4. Molecular Formula: C13H8ClN3O
    5. Molecular Weight: 257.679
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 27199-40-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 445°Cat760mmHg
    3. Flash Point: 222.9°C
    4. Appearance: /
    5. Density: 1.4372 (rough estimate)
    6. Vapor Pressure: 1.07E-07mmHg at 25°C
    7. Refractive Index: 1.6000 (estimate)
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. Water Solubility: 1.3g/L(37 oC)
    11. CAS DataBase Reference: Pifexole(CAS DataBase Reference)
    12. NIST Chemistry Reference: Pifexole(27199-40-2)
    13. EPA Substance Registry System: Pifexole(27199-40-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 27199-40-2(Hazardous Substances Data)

27199-40-2 Usage

Uses

Used in Neurological Applications:
Pifexole is used as a dopamine agonist for the treatment of Parkinson's disease and other neurological conditions. It increases dopamine levels in the brain, improving motor function and reducing symptoms such as tremors, rigidity, and slow movements.
Used in Psychiatric Applications:
Pifexole is used as a potential treatment for depression and other psychiatric disorders due to its effects on the brain's neurotransmitter system. Its ability to modulate neurotransmitter levels may contribute to its therapeutic effects in these conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 27199-40-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,1,9 and 9 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 27199-40:
(7*2)+(6*7)+(5*1)+(4*9)+(3*9)+(2*4)+(1*0)=132
132 % 10 = 2
So 27199-40-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H8ClN3O/c14-11-4-2-1-3-10(11)13-16-12(17-18-13)9-5-7-15-8-6-9/h1-8H

27199-40-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(2-chlorophenyl)-3-pyridin-4-yl-1,2,4-oxadiazole

1.2 Other means of identification

Product number -
Other names 4-[5-(2-chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:27199-40-2 SDS

27199-40-2Downstream Products

27199-40-2Relevant articles and documents

Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles

Tolmachev, Andrey,Bogolubsky, Andrey V.,Pipko, Sergey E.,Grishchenko, Alexander V.,Ushakov, Dmytro V.,Zhemera, Anton V.,Viniychuk, Oleksandr O.,Konovets, Anzhelika I.,Zaporozhets, Olga A.,Mykhailiuk, Pavel K.,Moroz, Yurii S.

, p. 616 - 624 (2016/10/21)

One-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids and nitriles was optimized to parallel chemistry. The method was validated on a 141 member library; the desired products were recovered with a high success rate and in moderate yields. Practical application of the approach was demonstrated in the synthesis of bioactive compound pifexole and agonists of free fatty acid receptor 1. A library of 4 948 100 synthesizable drug-like 3,5-disubstituted 1,2,4-oxadiazoles was enumerated based on the method and available validated reagents.

Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists

-

, (2008/06/13)

The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

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