27230-58-6

Basic information

• Product Name: (5-bromofuran-2-yl)methanol
• Synonyms: 5-bromo-2-Furanmethanol;2-Bromo-5-(hydroxymethyl)furan;(5-Bromofuran-2-yl);(5-bromofuran-2-yl)methanol
• CAS NO: 27230-58-6
• Molecular Formula: C₅H₅BrO₂
• Molecular Weight: 177
• Mol File: 27230-58-6.mol

Chemical Properties

• Boiling Point: 90 °C(Press: 10 Torr)
• Appearance: /
• Density: 1.731±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 13.63±0.10(Predicted)
• CAS DataBase Reference: (5-bromofuran-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (5-bromofuran-2-yl)methanol(27230-58-6)
• EPA Substance Registry System: (5-bromofuran-2-yl)methanol(27230-58-6)

Safety Data

• Hazardous Substances Data: 27230-58-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(5-bromofuran-2-yl)methanol is used as a key intermediate in the synthesis of various pharmaceutical compounds due to its unique structure and reactivity. Its presence in the molecular framework can contribute to the development of new drugs with improved therapeutic properties.
Used in Organic Chemistry:
As a furan derivative, (5-bromofuran-2-yl)methanol is utilized in organic chemistry for the synthesis of a wide range of organic molecules. Its versatility allows for the creation of diverse chemical entities with potential applications in various fields.
Used in Agrochemical and Pesticide Production:
(5-bromofuran-2-yl)methanol serves as a building block for the production of agrochemicals and pesticides. Its incorporation into these compounds can enhance their effectiveness in protecting crops and controlling pests.
Used in Anticancer Research:
(5-bromofuran-2-yl)methanol has been studied for its potential as an anticancer agent. Its unique structure may contribute to the development of new cancer treatments, offering hope for improved patient outcomes.
Used in Anti-inflammatory Drug Development:
(5-bromofuran-2-yl)methanol has also been investigated for its anti-inflammatory properties. (5-bromofuran-2-yl)methanol could be a key component in the development of new anti-inflammatory drugs, providing relief for individuals suffering from inflammation-related conditions.

Upstream product

• 1899-24-7 5-bromo-2-furancarboxaldehyde 

Downstream Products

• 33342-26-6 [5-(4-fluorophenyl)furan-2-yl]methanol 
• 22078-90-6 2-hydroxymethyl-5-phenylfuran 
• 216086-64-5 4-(5-phenylfur-2-ylmethyloxymethyl)-2-(2-methylphenyl)benzoic acid methyl ester 
• 251649-67-9 2-bromo-5-(bromomethyl)furan 
• 1352481-41-4 (4R,6S)-4-((2S,3S)-3-(benzyloxy)-2-(4-methoxybenzyloxy)butyl)-6-(2-(5-((tertbutyldimethylsilyloxy)methyl)furan-2-yl)propan-2-yl)-2,2-diisopropyl-1,3,2-dioxasilinane 
• 1352481-42-5 5-(2-((4S,6R)-6-((2S,3S)-3-(benzyloxy)-2-hydroxybutyl)-2,2-diisopropyl-1,3,2-dioxasilinan-4-yl)propan-2-yl)furan-2-carbaldehyde 
• 1352481-43-6 (E)-((2S,3S)-3-(benzyloxy)-1-((4R,6S)-6-(2-(5-formylfuran-2-yl)propan-2-yl)-2,2-diisopropyl-1,3,2-dioxasilinan-4-yl)butan-2-yl) but-2-enoate 
• 1352481-44-7 C₃₂H₄₆O₇Si 
• 1352481-46-9 C₃₂H₄₈O₇Si 
• 1352481-47-0 C₃₂H₄₆O₇Si 
• 1352481-48-1 C₃₂H₄₈O₇Si 
• 1352481-49-2 C₃₈H₆₀O₇Si₂ 
• 1352481-50-5 C₃₈H₆₂O₉Si₂ 
• 1352481-51-6 C₄₄H₇₆O₉Si₃ 

Relevant articles and documents

Intramolecular reactions of alkynes with furans and electron rich arenes catalyzed by PtCl2: The role of platinum carbenes as intermediates

5-(2-Furyl)-1-alkynes react, with PtCl2 as catalyst, to give phenols. On the basis of DFT calculations, a cyclopropyl platinacarbene complex was found as the key intermediate in the process. The cyclopropane and dihydrofuran rings of this intermediate open to form a carbonyl compound, which reacts with the platinum carbene to form an oxepin, which is in equilibrium with an arene oxide. When the reaction is carried out in the presence of water, dicarbonyl compounds are obtained, which support the proposed mechanism. Other cyclizations of alkynes with furans or electron-rich arenes give products of apparent Friedel-Crafts-type reactions, although these processes could also proceed by pathways involving the formation of cyclopropyl platinum carbenes.

REACTIONS OF ALDEHYDES OF THE FURAN SERIES. 3. OXIDATIVE-REDUCTIVE CONVERSIONS ON THE SURFACE OF ALKALI GRANULES

Furan aldehydes undergo an oxidative-reductive disproportionation over solid alkali in a solvent inert to alkali.Molecular oxygen increases the yield of the furan carboxylic acid.A reaction scheme is proposed that takes into account the important role of alkoholates of gem-polyols.