272437-84-0

Usage

Uses

Used in Pharmaceutical Industry:
3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid is used as a drug candidate for the development of new medications due to its potential anti-inflammatory properties, which may help in managing inflammation-related conditions.
Used in Antibacterial Applications:
In the field of microbiology, 3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid is utilized as an antibacterial agent, leveraging its capacity to combat bacterial infections, which could be instrumental in the creation of new antibiotics.
Used in Anticancer Research:
3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid is employed as a potential anticancer agent, with ongoing research exploring its ability to inhibit the growth and proliferation of cancer cells, offering a new avenue for cancer treatment.
Used in Enzyme and Receptor Inhibition:
In biochemical research, 3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid is used to inhibit certain enzymes and receptors, which may have implications for the treatment of various diseases where these enzymes or receptors play a critical role.

Upstream product

• 204863-51-4 4-ethoxycarbonylmethylsulfanyl-3-nitrobenzoic acid 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 188614-01-9 methyl 3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxylate 
• 204863-53-6 ethyl 3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxylate 

Downstream Products

• 1236221-12-7 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid {1-[2-(7-methoxy-quinoxalin-2-ylsulfanyl)-ethyl]-piperidin-4-yl}-methyl-amide 
• 1236221-13-8 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid {1-[2-(6-methoxy-quinolin-3-ylsulfanyl)-ethyl]-piperidin-4-yl}-amide 
• 1236220-60-2 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid {1-[2-(7-methoxy-quinoxalin-2-yloxy)-ethyl]-piperidin-4-yl}-amide 
• 1392138-96-3 C₂₃H₂₄FN₃O₂S 
• 1392139-43-3 C₂₃H₂₄FN₃O₂S 
• 1392139-47-7 C₂₃H₂₄FN₃O₂S 
• 1392139-48-8 C₂₃H₂₄FN₃O₂S 
• 1392139-49-9 C₂₃H₂₃F₂N₃O₂S 
• 1392139-50-2 C₂₃H₂₃F₂N₃O₂S 
• 1392139-52-4 C₂₇H₂₇N₃O₂S 
• 1392138-95-2 C₂₃H₂₆FN₃O₂S 
• 1392139-35-3 2-(2-fluorobenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxylic acid 
• 1392138-97-4 C₂₃H₂₄FN₃O₂S 
• 1392138-98-5 C₂₄H₂₆FN₃O₂S 

Relevant academic research and scientific papers

Discovery of a Plasmodium falciparum Glucose-6-phosphate Dehydrogenase 6-phosphogluconolactonase Inhibitor (R,Z)-N-((1-Ethylpyrrolidin-2-yl)methyl)-2- (2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro

A high-throughput screen of the NIH's MLSMR collection of ～340000 compounds was undertaken to identify compounds that inhibit Plasmodium falciparum glucose-6-phosphate dehydrogenase (Pf G6PD). PfG6PD is important for proliferating and propagating P. falciparum and differs structurally and mechanistically from the human orthologue. The reaction catalyzed by glucose-6-phosphate dehydrogenase (G6PD) is the first, rate-limiting step in the pentose phosphate pathway (PPP), a key metabolic pathway sustaining anabolic needs in reductive equivalents and synthetic materials in fast-growing cells. In P. falciparum, the bifunctional enzyme glucose-6-phosphate dehydrogenase-6- phosphogluconolactonase (Pf GluPho) catalyzes the first two steps of the PPP. Because P. falciparum and infected host red blood cells rely on accelerated glucose flux, they depend on the G6PD activity of PfGluPho. The lead compound identified from this effort, (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2- fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carbox-amide, 11 (ML276), is a submicromolar inhibitor of PfG6PD (IC50 = 889 nM). It is completely selective for the enzyme's human isoform, displays micromolar potency (IC50 = 2.6 μM) against P. falciparum in culture, and has good drug-like properties, including high solubility and moderate microsomal stability. Studies testing the potential advantage of inhibiting Pf G6PD in vivo are in progress.

SUBSTITUTED 2-BENZYLIDENE-2H-BENZO[b][1,4]THIAZIN-3(4H)-ONES, DERIVATIVES THEREOF, AND THERAPEUTIC USES THEREOF

The present invention relates to compounds according to Formula I and salts thereof, wherein R1, R2, R3, R4, Ar, and n are as defined herein. Methods for preparing compounds of Formula I are also provided. The present invention further includes methods of treating cellular proliferative disorders, such as cancer, with the compounds of Formula I.

Bicyclic pyrazole compounds as antibacterial agents

Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.

AMINE COMPOUNDS

The present invention provide a compound of the formula:wherein ring A represents an aromatic ring optionally having substituents; B, Y and Ya are the same or different and each represents a bond, etc.; R1 and R2 are the same or different and each represents a hydrogen atom, etc.; R3 represents a hydrogen atom, etc.; R4 and R5 are the same or different and each represents a hydrogen, etc.; R6 represents an indolyl group optionally having substituents; and Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibition activity and is useful for preventing and/or treating diseases associated with somatostatin.

ANTIBACTERIAL COMPOUNDS

Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man

NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS

Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives hereof useful in methods of treatment of bacterial infections in mammals, particularly man.