Tetralone esters as intermediates for the synthesis of podophyllotoxin derivatives via cyclopropanation of chalcones
Cyclopropyl ester (8a-f) were synthesized by the cyclopropanation of chalcones (7a-e) in dry benzene using powdered sodium in 80-85% yield. Preparation of tetralone ester (4a-e), an intermediate for the synthesis of podophyllotoxin derivatives by Lewis ac