- Construction of novel steroidal isoxazolidinone derivatives under Vilsmeier-Haack conditions
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A novel expeditious and convenient synthesis of 5α-cholestano-[5,6-c] -isoxazolidin-5′-ones based on the reaction of 5α-6- hydroxyiminocholestanes with Vilsmeier-Haack reagent (DMF/POCl3) is described. The systems presented here, are novel scaffolds and have not been described before. Structural assignment of newly synthesized compounds was performed by IR, 1H NMR, 13C NMR, 2D 1H- 1H COSY, MS and analytical data.
- Shamsuzzaman,Khanam, Hena,Mashrai, Ashraf,Siddiqui, Nazish
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- Reduction of Steroidal Nitroolefins with Zinc-Acetic Acid without Added Water
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Zinc-acetic acid reduction (without added water) of steroidal nitroolefins (I-III) leads to the formation of respective N-acetylated enamines (X-XII) alongwith the parent ketones (IV-VI) and the oximes (VII-IX).These products have been identified on the basis of their spectral properties and by comparison with authentic samples where available.
- Ahmad, M. S.,Raza, S. K.
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p. 579 - 580
(2007/10/02)
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- Thermolytic Transformation of Steroidal Nitroimines
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Thermolysis of 6-nitroimino-5α-cholestan-3β-yl acetate (I), 6-nitroimino-5α-cholestane (VII) and 7-nitroiminocholest-5-en-3β-yl chloride (XII) in refluxing xylene affords a mixture of products in the case of I and VII and a chlorine-free product in the case of XII.The known products have been characterized by direct comparison while unknown products by elemental analyses and spectral data.
- Ahmad, M. S.,Raza, S. K.
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p. 259 - 260
(2007/10/02)
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- A Novel Method for Preparation of Steroidal Ketoximes from Nitroolefins
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Steroidal 6-nitroolefins (I-IV) undergo facile reaction with NH3-MeOH-Zn yielding exclusively the corresponding 6-one oximes (V-VIII) in quantitative yields.The method appears to be of general applicability.
- Habib, Rubina,Husain, Mubarak,Husain, Mashkoor,Khan, Naseem H.
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