274682-91-6

Basic information

• Product Name: 2,4-DIFLUOROPHENYLACETONE
• Synonyms: 2,4-DIFLUOROPHENYLACETONE;2,4-Difluorophenylacetone,98%;1-(2,4-difluorophenyl)propan-2-one
• CAS NO: 274682-91-6
• Molecular Formula: C₉H₈F₂O
• Molecular Weight: 170.16
• Product Categories: Aromatic Ketones (substituted)
• Mol File: 274682-91-6.mol

Chemical Properties

• Boiling Point: 201.3±25.0 °C(Predicted)
• Appearance: Clear yellow/Liquid
• Density: 1.179±0.06 g/cm3(Predicted)
• Refractive Index: 1.477-1.479
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,4-DIFLUOROPHENYLACETONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIFLUOROPHENYLACETONE(274682-91-6)
• EPA Substance Registry System: 2,4-DIFLUOROPHENYLACETONE(274682-91-6)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 274682-91-6(Hazardous Substances Data)

Usage

Chemical Properties

Clear yellow liquid

Upstream product

• 108-22-5 Isopropenyl acetate 
• 367-25-9 2,4-difluorophenylamine 

Downstream Products

• 127000-91-3 (2R,3R)-3-Amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 
• 124627-86-7 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole 
• 132507-89-2 (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol 
• 164650-45-7 (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidine-1-yl)-1-(1H-1,2,4-triazole-1-yl)-butane-2-ol 

Relevant articles and documents

Asymmetric Catalytic Epoxidation of Terminal Enones for the Synthesis of Triazole Antifungal Agents

An enantioselective epoxidation of α-substituted vinyl ketones was realized to construct the key epoxide intermediates for the synthesis of various triazole antifungal agents. The reaction proceeded efficiently in high yields with good enantioselectivities by employing a chiral N,N′-dioxide/ScIII complex as the chiral catalyst and 35% aq. H2O2 as the oxidant. It enabled the facile transformation for optically active isavuconazole, efinaconazole, and other potential antifungal agents.

Process for the preparation of strobilurin intermediates

The present invention relates to a novel improved process and intermediates for the process of preparing the oxime intermediates of formula (II) wherein R1is hydrogen, fluoro or chloro, and R2is methyl, ethyl, methoxy, ethoxy, triflu