275388-05-1Relevant articles and documents
Synthesis of a Novel Rhizobitoxine-Like Triazole-Containing Amino Acid
Boibessot, Thibaut,Bénimèlis, David,Jean, Marion,Benfodda, Zohra,Meffre, Patrick
supporting information, p. 2685 - 2688 (2016/11/30)
The synthesis of the four stereoisomers of a new 1,2,3-triazole analogue of rhizobitoxine from serine is described. The key step is a Huisgen 1,3-dipolar cycloaddition on an ethynylglycine synthon.
4-Alkenyl- and 4-alkynyloxindoles
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, (2008/06/13)
Disclosed are novel 4-alkenyl- and 4-alkynyl oxindoles having the formula and the pharmaceutically acceptable salts thereof, wherein R1, R2, R3, a, b, and X are as defined herein. These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. These compounds and their pharmaceutically acceptable salts, and prodrugs of said compounds, are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular cancer, more particularly, the treatment or control of breast and colon tumors. Also disclosed are pharmaceutical compositions containing the compounds of formula I and II as well as intermediates useful in the preparation of the compounds of formula I and II.
En route to optically active ethynylglycine derivatives
Meffre, Patrick,Gauzy, Laurence,Perdigues, Chantal,Desanges-Levecque, Florence,Branquet, Eric,Durand, Philippe,Le Goffic, Francois
, p. 877 - 880 (2007/10/02)
First results in the synthesis of chiral non racemic ethynylglycine derivatives from protected L-serinal are described.
