276875-21-9

Basic information

• Product Name: 1-(3',4'-DIFLUOROPHENYL)ETHYLAMINE
• Synonyms: 1-(3,4-Difluorophenyl)ethaneamine;1-(3',4'-DIFLUOROPHENYL)ETHYLAMINE;1-(3,4-DIFLUOROPHENYL)ETHANAMINE;Benzenemethanamine, 3,4-difluoro-alpha-methyl- (9CI)
• CAS NO: 276875-21-9
• Molecular Formula: C8H9F2N
• Molecular Weight: 157.16
• Product Categories: Anilines, Amides & Amines;Fluorine Compounds;HALIDE
• Mol File: 276875-21-9.mol

Chemical Properties

• Boiling Point: 186.1 °C at 760 mmHg
• Flash Point: 81.4 °C
• Appearance: /
• Density: 1.163 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 1-(3',4'-DIFLUOROPHENYL)ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3',4'-DIFLUOROPHENYL)ETHYLAMINE(276875-21-9)
• EPA Substance Registry System: 1-(3',4'-DIFLUOROPHENYL)ETHYLAMINE(276875-21-9)

Safety Data

• Hazard Codes: Xn
• Statements: 34-22
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• Hazardous Substances Data: 276875-21-9(Hazardous Substances Data)

Usage

Uses

1-(3'',4''-Difluorophenyl)ethylamine

Upstream product

• 369-33-5 3',4'-difluoroacetophenone 
• 276875-21-9 1-(3,4-difluorophenyl)ethanamine 
• 1434602-13-7 (E)-1-(3,4-difluorophenyl)ethan-1-one oxime 
• 1434602-38-6 (E)-1-(3,4-difluorophenyl)ethanone O-benzyloxime 

Downstream Products

• 276875-21-9 C₈H₉F₂N 
• 369-33-5 3',4'-difluoroacetophenone 
• 321318-17-6 (S)-1-(3,4-difluorophenyl)ethanamine 
• 1434602-62-6 (S)-N-[1-(3,4-difluorophenyl)ethyl]acetamide 

Relevant articles and documents

Deracemization of Racemic Amines to Enantiopure (R)- and (S)-amines by Biocatalytic Cascade Employing ω-Transaminase and Amine Dehydrogenase

A one-pot deracemization strategy for α-chiral amines is reported involving an enantioselective deamination to the corresponding ketone followed by a stereoselective amination by enantiocomplementary biocatalysts. Notably, this cascade employing a ω-transaminase and amine dehydrogenase enabled the access to both (R)-and (S)-amine products, just by controlling the directions of the reactions catalyzed by them. A wide range of (R)-and (S)-amines was obtained with excellent conversions (>80 %) and enantiomeric excess (>99 % ee). Finally, preparative scale syntheses led to obtain enantiopure (R)- and (S)-13 with the isolated yields of 53 and 75 %, respectively.

Identification of novel thermostable ω-transaminase and its application for enzymatic synthesis of chiral amines at high temperature

A novel thermostable ω-transaminase from Thermomicrobium roseum which showed broad substrate specificity and high enantioselectivity was identified, expressed and biochemically characterized. The advantage of this enzyme to remove volatile inhibitory by-products was demonstrated by performing asymmetric synthesis and kinetic resolution at high temperature.

PROCESS FOR THE PREPARATION OF CHIRAL AMINES FROM PROCHIRAL KETONES

There is provided a method for the preparation of an enantiomerically enriched amine from a prochiral ketone.

Bioinspired organocatalytic aerobic C-H oxidation of amines with an ortho -quinone catalyst

A simple bioinspired ortho-quinone catalyst for the aerobic oxidative dehydrogenation of amines to imines is reported. Without any metal cocatalysts, the identified optimal ortho-quinone catalyst enables the oxidations of α-branched primary amines and cyclic secondary amines. Mechanistic studies have disclosed the origins of different performances of ortho-quinone vs para-quinone in biomimetic amine oxidations.

3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH

The invention is directed to a formula (I), or a pharmamceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

Asymmetric synthesis of nonracemic primary amines via spiroborate-catalyzed reduction of pure (E)- and (Z)-O-benzyloximes: Applications toward the synthesis of calcimimetic agents

Highly enantiopure (1-aryl)- and (1-naphthyl)-1-ethylamines were synthesized by the borane-mediated reduction of single-isomeric (E)- and (Z)-O-benzyloxime ethers using the stable spiroborate ester derived from (S)-diphenyl valinol and ethylene glycol as the chiral catalyst. Primary (R)-arylethylamines were prepared by the reduction of pure (Z)-ethanone oxime ethers in up to 99% ee using 15% of catalyst. Two convenient and facile approaches to the synthesis of new and known calcimimetic analogues employing enantiopure (1-naphthalen-1-yl)ethylamine as chiral precursor are described.

One-pot one-step deracemization of amines using ω-transaminases

In this study, we developed a one-pot one-step deracemization method for the production of various enantiomerically pure amines using two opposite enantioselective ω-TAs. Using this method, various aromatic amines were successfully converted to their (R)-forms (>99%) with good conversion.