- Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism
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Doxorubicin (DOX) and daunorubicin (DAUN) are anthracycline anticancer agents; however, considerable interpatient variability exists in their pharmacokinetics. This interpatient variability is attributed in part to altered metabolism by nonsynonymous sing
- Bains, Onkar S.,Karkling, Morgan J.,Lubieniecka, Joanna M.,Grigliatti, Thomas A.,Reid, Ronald E.,Riggs, K. Wayne
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experimental part
p. 755 - 763
(2011/10/31)
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- DAUNORUBICIN ALDO-KETO REDUCTASES: ENANTIOFACE DIFFERENTIAL REDUCTION OF THE SIDE-CHAIN CARBONYL GROUP OF ANTITUMOR ANTHRACYCLINES. CORRECTION OF THE STEREOCHEMISTRY AT C(13) OF 4-DEMETHOXY-13-DIHYDRODAUNORUBICIN
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The main urine metabolites of daunorubicin, 1, doxorubicin, 3, and idarubicin, 5, have been isolated and identified as the corresponding 13-dihydro derivatives 2, 4, and 6, respectively. 1H NMR examination of the corresponding protected aglycones allows the assignment of the S configuration to the C(13) chiral centre.
- Penco, Sergio,Cassinelli, Giuseppe,Vigevani, Aristide,Zini, Pierangelo,Rivola, Giovanni,Arcamone, Federico
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p. 195 - 198
(2007/10/02)
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- Anthracycline glycoside compositions, their use and preparation
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Anthracycline glycoside antibiotics are complexed with cardiolipin and then encapsulated in liposomes to reduce mammalian cardiac tissue uptake of the anthracycline glycoside and to thereby reduce the deleterious effect of such cardiac tissue uptake. The invention is directed to the composition, preparation and use of the encapsulated complex of anthracycline glycoside.
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