- Asymmetric synthesis of β-fluoroaryl-β-amino acids
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The conjugate addition of lithium (R)-N-benzyl-N-(α-methylbenzyl) amide to a range of β-fluoroaryl-α,β-unsaturated esters gave the corresponding β-amino esters with high diastereoselectivity and in good isolated yields. Sequential treatment of the resulta
- Davies, Stephen G.,Fletcher, Ai M.,Lv, Linlu,Roberts, Paul M.,Thomson, James E.
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experimental part
p. 910 - 925
(2012/09/22)
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- N-4-PIPERIDINYL COMPOUNDS AS CCR5 MODULATORS
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The invention provides a compound of formula (I):[Chemical formula should be inserted here. Please see paper copy.] wherein R1, R2, R3, R3a, R4, R4a, R5, and R6 are as defined; or a pharmaceutically acceptable salt thereof or a solvate thereof; compositions containing these compounds, processes for preparing them and their use as modulators of chemokine activity (especially CCR5 activity).
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