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Methyl 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propanoate is a chemical compound with the molecular formula C16H20ClNO4. It is a derivative of propanoic acid and features a tert-butoxycarbonyl (Boc) protecting group and a chlorophenyl substituent. methyl 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propanoate is recognized for its utility in organic synthesis, particularly as a building block for the preparation of pharmaceuticals and agrochemicals. Its structural attributes render it suitable for the synthesis of a diverse array of biologically active compounds, and the presence of the Boc-protected amino group positions it as a key intermediate in the synthesis of peptides and other complex molecules.

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  • 277745-47-8 Structure
  • Basic information

    1. Product Name: methyl 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propanoate
    2. Synonyms: methyl 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propanoate;BENZENEPROPANOIC ACID, 4-CHLORO-BETA-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-, METHYL ESTER
    3. CAS NO:277745-47-8
    4. Molecular Formula: C15H20ClNO4
    5. Molecular Weight: 313.7766
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 277745-47-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: methyl 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propanoate(CAS DataBase Reference)
    10. NIST Chemistry Reference: methyl 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propanoate(277745-47-8)
    11. EPA Substance Registry System: methyl 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propanoate(277745-47-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 277745-47-8(Hazardous Substances Data)

277745-47-8 Usage

Uses

Used in Pharmaceutical Synthesis:
Methyl 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propanoate serves as a crucial building block in the pharmaceutical industry for the creation of various medicinal compounds. Its unique structure allows for the development of drugs with specific therapeutic targets, contributing to the advancement of novel treatment options.
Used in Agrochemical Development:
In the agrochemical sector, this compound is utilized to synthesize active ingredients for pesticides and other crop protection agents. Its role in formulating effective and targeted agrochemicals aids in enhancing crop yields and ensuring food security.
Used as a Peptide Synthesis Intermediate:
The presence of the Boc-protected amino group in methyl 3-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propanoate makes it an indispensable intermediate in peptide synthesis. It facilitates the stepwise assembly of peptide chains, which is vital for the production of bioactive peptides and protein-based drugs.
Used in Organic Synthesis for Biologically Active Compounds:
Beyond its applications in pharmaceuticals and agrochemicals, this compound is also employed in organic synthesis to create a broad spectrum of biologically active molecules. Its versatility in synthesis allows researchers to explore new chemical entities with potential applications in various biological and medical fields.

Check Digit Verification of cas no

The CAS Registry Mumber 277745-47-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,7,7,4 and 5 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 277745-47:
(8*2)+(7*7)+(6*7)+(5*7)+(4*4)+(3*5)+(2*4)+(1*7)=188
188 % 10 = 8
So 277745-47-8 is a valid CAS Registry Number.

277745-47-8Downstream Products

277745-47-8Relevant articles and documents

PYRROLO [2,3-D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS

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Page/Page column 96, (2009/05/30)

The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I)

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