Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials
Novel benzazepine oxazolidinone antibacterials were synthesized and evaluated against clinically relevant susceptible and resistant organisms. The effect of ring nitrogen position and N-substitution on antibacterial activity is examined.
Johnson, Paul D.,Aristoff, Paul A.,Zurenko, Gary E.,Schaadt, Ronda D.,Yagi, Betty H.,Ford, Charles W.,Hamel, Judith C.,Stapert, Douglas,Moerman, Judy K.
p. 4197 - 4200
(2007/10/03)
Condensed heterocyclic compounds, their production and use
A condensed heterocyclic derivative of the formula (I): STR1 wherein X is an oxygen atom, a sulfur atom or R1 --N1 is a hydrogen atom, a hydrocarbon group which may be substituted or an acyl group which may be substituted; R2 is a hydrogen atom or a hydrocarbon group which may be substituted; ring A is a benzene ring which may be substituted, k is a whole number of 0 to 3; m is a whole number of 1 to 8; and n is a whole number of 1 to 6, or a pharmaceutically acceptable salt thereof exhibiting high colinesterase inhibitory activity, and a method for producing the same.
-
(2008/06/13)
More Articles about upstream products of 27912-16-9
