Substituted heterocyclic compound, and use method and use thereof
The invention relates to a substituted heterocyclic compound, and a use method and a use thereof. The substituted heterocyclic compound and a medicinal composition including the compound can be used to depress orexin receptors, especially an orexin-1 rece
Simple microwave-assisted ligand-free Suzuki cross-coupling: Functionalization of halo-pyrimidine moieties
(Chemical Equation Presented) An advantageous ligand-free protocol for Suzuki couplings is described. The synthetic procedure entails microwave irradiation for the reduction of the reaction times and the use of silica cartridges for the purification. Dihalo-pyrimidine structures, interesting scaffolds in medicinal chemistry, were chosen as test compounds.
Colombo, Matteo,Giglio, Marco,Peretto, Ilaria
p. 1077 - 1081
(2008/12/20)
Synthesis and biological activities of novel β-carbolines as PDE5 inhibitors
A series of N2-furoyl and N2pyrimidinyl β-carbolines was discovered to possess potent inhibitory activity against PDE5. During the synthesis we developed a tandem resin quenching protocol, which allowed us to synthesize large number
Sui, Zhihua,Guan, Jihua,Macielag, Mark J.,Jiang, Weiqin,Qiu, Yuhong,Kraft, Patricia,Bhattacharjee, Sheela,John, T. Matthew,Craig, Elizabeth,Haynes-Johnson, Donna,Clancy, Joanna
p. 761 - 765
(2007/10/03)
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