Phase transfer catalyst in grindstone synthesis of 3-oxopropanenitrile: One pot synthesis of polysubstituted amino thiophenes
The chemoselective SN2 reaction of ω-bromoacetophenone with sodium cyanide or potassium cyanide in DMF-water or in biphasic solvent toluene-water using tetrabutylammonium bromide (TBAB) as phase-transfer catalyst, performed by grinding, furnished 3-oxopropanenitriles 2 as the sole product in 70-80% yield, while in ethanolwater, mixture of compound 2 and oxirane 3 were obtained. The obtained 3-oxopropanenitriles 2 were used for one pot synthesis of 2-amino-3-carbonitrile thiophenes.
Patil, Shivaraj P.,Kanawade, Shrikant B.,Shinde, Madhukar P.,Toche, Raghunath B.
p. 33 - 36
(2013/09/24)
Formation of oxiranes during the preparation of aroylacetonitriles
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Toche,Jachak,Badgujar,Avhale,Kendre
p. 405 - 408
(2007/10/03)
Regioselective reactions of phenacyl bromide with active methylene compounds
The reactivity of phenacyl bromide with active methylene compounds in the presence of alcoholic KOH, BTEAC (PTC), NaOEt and K2CO3 has been studied.
Padmavathi,Balaiah,Reddy, M. Muralidhar,Reddy, D. Bhaskar
p. 1519 - 1522
(2007/10/03)
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