Synthesis of the diazatricyclic core of madangamines via cyclic N,O-acetalization-bridgehead reduction
A new approach to synthesize the diazatricyclic core of the madangamine alkaloids is described. The synthesis involves intramolecular N,O-acetalization of the keto-aminophenol which enables rapid construction of the 2-azabicyclo[3.3.1]nonane skeleton. Red