Efficient chemoenzymatic synthesis of enantiomerically pure β-heterocyclic amino acid derivatives
Enantiomerically pure (S)-pyrazolylalanine and its derivatives are nonproteinogenic amino acids with antidiabetic activity. A short and effective enantioselective synthesis of these compounds is described, using a kinetic resolution by an acylase from Aspergillus sp.
Rolland-Fulcrand, Valerie,Haroune, Nicolas,Roumestant, Maire-Louise,Martinez, Jean
p. 4719 - 4724
(2007/10/03)
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