- STABILIZED POLYPEPTIDES AND USES THEREOF
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The present invention provides inventive stabilized STAT polypeptides, pharmaceutical compositions thereof, and methods of making and using inventive stabilized STAT polypeptides.
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- TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES
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Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
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Page/Page column
(2013/08/28)
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- TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES
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Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
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Paragraph 00230
(2013/08/28)
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- The scope of catalytic enantioselective tandem carbonyl ylide formation - Intramolecular [3 + 2] cycloadditions
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Catalytic enantioselective tandem carbonyl ylide formation-intramolecular 1,3-dipolar cycloaddition reactions of 2-diazo-3,6-diketoesters show promising scope in terms of asymmetric induction as the tethered alkene/alkyne dipolarophile component is varied. Cycloadditions were found to occur in moderate to very good yields, with a difference in ee exhibited by the electronically different 2-diazo-3,6-diketoesters 1, 25 and 33, 34. Values for ee of up to 90% for alkene dipolarophiles and up to 86% for alkyne dipolarophiles were obtained.
- Hodgson, David M.,Labande, Agnes H.,Pierard, Francoise Y. T. M.,Exposito Castro, Maria A.
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p. 6153 - 6159
(2007/10/03)
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- An investigation of l,4,7-tri(4-alkynyl)-l,4,7-triazacyclononanes: Ligand synthesis and metal co-ordination chemistry
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Three triazacyclononanes bearing pendant alkynyl groups [l,4,7-tri(4-pentynyl)-l,4,7-triazacyclononane (ptacn), 1,4,7-tri(5-phenyl-4-pentynyl)-l,4,7-triazacyclononane (pptacn) and 1,4,7-tri(4-hexynyl)-1,4,7-triazacyclononane (4htacn)] have been synthesize
- Baker, Murray V.,Brown, David H.,Skelton, Brian W.,White, Allan H.
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p. 4607 - 4616
(2007/10/03)
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- Synthesis of Arylcycloalkanes from ω-Alkenyl Benzylselenides
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Arylcycloalkanes are produced from ω-alkenyl benzylselenides on reaction with alkyllithiums or on Lewis acid mediated electrophilic cyclisation.
- Krief, Alain,Kenda, Benoit,Barbeaux, Phillipe,Guittet, Eric
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p. 7177 - 7192
(2007/10/02)
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