Diversity oriented approach to polycyclic compounds through the diels-alder reaction and the Suzuki coupling
A diversity oriented strategy has been demonstrated to deliver small "drug like" molecules using alkylation, Diels-Alder reaction, and Suzuki-Miyaura cross-coupling as key steps. This methodology allows access a wide range of molecules using simple scaffolds such as indanes, tetralins and tetrahydroisoquinolines, which can enhance the chemical space for potential therapeutic molecules.
Kotha, Sambasivarao,Misra, Shilpi,Srinivas, Venu
scheme or table
p. 4052 - 4062
(2012/09/07)
SOLUBLE, PERSISTENT NONACENE DERIVATIVES
The present invention is directed towards a new class of semi-conducting nonacene derivatives. These compounds are all soluble species and they all possess superior resistance to oxidation as compared to their counterparts that lack the substitution patte
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Page/Page column 6
(2011/06/23)
Design, synthesis, and characterization of a persistent nonacene derivative
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Kaur, Irvinder,Jazdzyk, Mikael,Stein, Nathan N.,Prusevich, Polina,Miller, Glen P.
supporting information; experimental part
p. 1261 - 1263
(2010/04/01)
Studies on the Chemistry of Isoindoles and Isoindolenines, XXXI. 4,5,6,7-Tetrachloro-and 4,5,6,7-Tetrabromo-2H-isoindoles
The crystalline 2H-isoindoles 4b are synthesized starting with substituted 2-methylsulfonyl-2,3-dihydro-1H-isoindoles 3 by base-induced elimination of methanesulfinic acid.Compared with the parent compound, a considerable thermal stabilization and chemical deactivation is caused by the halogen atoms at the carbocyclic system.The spectroscopic properties of the o-quinonoid hetarenes 4b have been investigated.
Kreher, Richard P.,Herd, Karl Josef
p. 1827 - 1832
(2007/10/02)
SYNTHESIS OF 3-(ALKYLARYL)-1-ADAMANTANOLS
The possibility was demonstrated for removal of hydride ions from 1-(alkylaryl)adamantanes by tertiary carbocations generated from the corresponding alcohols or halides in trifluoroacetic acid leading to the formation of 3-(alkylaryl)-1-adamantanols in 40-60percent yield.In the case of 1-phenyladamantane, the major product is 1-(1-adamantyl)-4-benzene formed in 71percent yield due to presence of two reaction sites (the benzene ring para position and the tertiary carbon atom of the adamantane fragment) in the starting 1-phenyladamantane.
Kovalev, V. V.,Knyazeva, I. V.,Shokova, E. A.
p. 692 - 696
(2007/10/02)
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