28115-75-5

Basic information

• Product Name: POLYOXYETHYLENE 4 HEPTYL ETHER
• Synonyms: C7E4, TetraethyleneglycolMonoheptylether;POLYOXYETHYLENE 4 HEPTYL ETHER
• CAS NO: 28115-75-5
• Molecular Formula: C15H32O5
• Molecular Weight: 292.413
• Mol File: 28115-75-5.mol

Chemical Properties

• Boiling Point: 380.4°C at 760 mmHg
• Flash Point: 183.9°C
• Appearance: /
• Density: 0.977g/cm³
• Vapor Pressure: 2.38E-07mmHg at 25°C
• Refractive Index: 1.447
• CAS DataBase Reference: POLYOXYETHYLENE 4 HEPTYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: POLYOXYETHYLENE 4 HEPTYL ETHER(28115-75-5)
• EPA Substance Registry System: POLYOXYETHYLENE 4 HEPTYL ETHER(28115-75-5)

Safety Data

• Hazardous Substances Data: 28115-75-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H32O5/c1-2-3-4-5-6-8-17-10-12-19-14-15-20-13-11-18-9-7-16/h16H,2-15H2,1H3

Upstream product

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Relevant articles and documents

Bna Conjugates and Methods of Use

Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, decreasing arterial blood pressure and in some embodiments an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, enteral, subcutaneous, pulmonary, and intravenous forms of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the hBNP compound are also disclosed, having an amino acid sequence that is other than the native sequence.

Combinatorial synthesis of PEG oligomer libraries

A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.