Selective methylation of NH-containing heterocycles and sulfonamides using n, N -dimethylformamide dimethylacetal based on calculated pKa Measurements
The use of N,N-dimethylformamide dimethylacetal (DMF-DMA) as a suitable methylating agent for the methylation of NH-containing groups and heterocycles has been investigated. Use of ReactArray and calculated pKa measurements have allowed additional helpful information to be collated to determine optimum reaction conditions for a variety of substrates.
Fairley, Gary,Hall, Catherine,Greenwood, Ryan
p. 570 - 574
(2013/04/10)
A facile synthesis of 1-alkyl-7-azaisatins
1-Alkyl-7-azaisatins are synthesized from the reaction of 1-alkyl-7- azaindoles with bromine in dichloromethane and subsequent oxidation with N- bromosuccinimide - dimethyl sulfoxide reagent. 1-Alkyl-7-azaindoles are readily available in high yields from