281209-52-7Relevant articles and documents
Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor
Teng, Min,Johnson, Michael D.,Thomas, Christine,Kiel, Dan,Lakis, James N.,Kercher, Tim,Aytes, Shelley,Kostrowicki, Jarek,Bhumralkar, Dilip,Truesdale, Larry,May, John,Sidelman, Ulla,Kodra, Janos T.,Jorgensen, Anker Steen,Olesen, Preben Houlberg,de Jong, Johannes Cornelis,Madsen, Peter,Behrens, Carsten,Pettersson, Ingrid,Knudsen, Lotte Bjerre,Holst, Jens J.,Lau, Jesper
, p. 5472 - 5478 (2008/09/18)
Following our previous publication describing the biological profiles, we herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small molecule agonists for the hGLP-1 receptor.
NON-PEPTIDE GLP-1 AGONISTS
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Page/Page column 72-73, (2010/02/13)
Novel non-peptide GLP-1 agonists, pharmaceutical compositions comprising them, use of the non-peptide GLP-1 agonists for the preparation of pharmaceutical compositions and methods for the treatment and/or prevention of disorders and diseases wherein an ac