28123-73-1

Basic information

• Product Name: 5-(4-NITROPHENYL)-2-FUROIC ACID
• Synonyms: ASISCHEM T31195;ART-CHEM-BB B025354;AKOS BB-8339;5-(4-NITROPHENYL)-2-FURANCARBOXYLIC ACID;5-(4-NITROPHENYL)-2-FUROIC ACID;5-(4-NITRO-PHENYL)-FURAN-2-CARBOXYLIC ACID;RARECHEM AL BE 0741;5-(4-Nitrophenyl)-furane-2-carboxylic acid
• CAS NO: 28123-73-1
• Molecular Formula: C₁₁H₇NO₅
• Molecular Weight: 233.18
• Product Categories: API intermediates
• Mol File: 28123-73-1.mol

Chemical Properties

• Melting Point: 255-257 °C (dec.)(lit.)
• Boiling Point: 451.4°Cat760mmHg
• Flash Point: 226.8°C
• Appearance: /
• Density: 1.44g/cm³
• Vapor Pressure: 6.16E-09mmHg at 25°C
• CAS DataBase Reference: 5-(4-NITROPHENYL)-2-FUROIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-NITROPHENYL)-2-FUROIC ACID(28123-73-1)
• EPA Substance Registry System: 5-(4-NITROPHENYL)-2-FUROIC ACID(28123-73-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 28123-73-1(Hazardous Substances Data)

Usage

Uses

1. Used in Pharmaceutical Research:
5-(4-NITROPHENYL)-2-FUROIC ACID is used as a research compound for studying its metabolic pathways and interactions with other molecules. Its identification in biological samples helps in understanding the metabolism of dantrolene and its potential effects on muscle spasm conditions.
2. Used in Analytical Chemistry:
In the field of analytical chemistry, 5-(4-NITROPHENYL)-2-FUROIC ACID is used as a reference compound for the development and validation of HPLC methods. Its detection and quantification in plasma and urine samples contribute to the assessment of dantrolene's pharmacokinetics and pharmacodynamics.
3. Used in Drug Metabolism Studies:
5-(4-NITROPHENYL)-2-FUROIC ACID is used as a metabolite of interest in drug metabolism studies. Researchers can investigate the enzymes and pathways involved in the conversion of dantrolene to this metabolite, which may provide insights into the drug's mechanism of action and potential side effects.
4. Used in Toxicology:
In toxicology, 5-(4-NITROPHENYL)-2-FUROIC ACID can be used to study the potential toxic effects of dantrolene and its metabolites. Understanding the toxicokinetics and toxicodynamics of 5-(4-NITROPHENYL)-2-FUROIC ACID can help in the development of safer and more effective treatments for muscle spasm conditions.
5. Used in Quality Control:
5-(4-NITROPHENYL)-2-FUROIC ACID is used as a quality control standard in the pharmaceutical industry. It can be employed to ensure the accuracy and reliability of analytical methods used in the production and testing of dantrolene and its formulations.

InChI:InChI=1/C11H7NO5/c13-11(14)10-6-5-9(17-10)7-1-3-8(4-2-7)12(15)16/h1-6H,(H,13,14)/p-1

Upstream product

• 88-14-2 2-furanoic acid 
• 100-01-6 4-nitro-aniline 
• 98-01-1 furfural 
• 52939-00-1 5-(4-nitrophenyl)furan-2-carboxylic acid methyl ester 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 24067-17-2 4-nitrophenylboronic acid 
• 7147-77-5 5-(4-nitrophenyl)-2-furaldehyde 

Downstream Products

• 226710-79-8 tert-butyl N-<2-(5-p-nitrophenylfuryl)>carbamate 
• 500604-97-7 N-[(1S,2R,4R)-7-azabicyclo[2.2.1]hept-2-yl]-5-(4-nitrophenyl)-2-furamide hydrochloride 
• 69333-30-8 1-methyl-4-piperidyl 5-(p-nitrophenyl)-2-furoate hydrochloride 
• 627041-09-2 3-(2-furyl)-6-[5-(4-nitrophenyl)furan-2-yl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 1410785-78-2 C₁₉H₁₃N₃O₅ 
• 1410785-79-3 C₂₀H₁₅N₃O₅ 
• 140160-21-0 5-(4-Nitro-phenyl)-furan-2-carbonyl isothiocyanate 
• 847981-73-1 1-(4-hydroxy-6-methyl-pyrimidin-2-yl)-3-[5-(4-nitro-phenyl)-furan-2-carbonyl]-thiourea 
• 873098-06-7 1-(4,6-diethoxy-pyrimidin-2-yl)-3-[5-(4-nitro-phenyl)-furan-2-carbonyl]-thiourea 

Relevant articles and documents

Discovery of a series of 5-phenyl-2-furan derivatives containing 1,3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors

Gut microbial β-glucuronidases have drawn much attention due to their role as a potential therapeutic target to alleviate some drugs or their metabolites-induced gastrointestinal toxicity. In this study, fifteen 5-phenyl-2-furan derivatives containing 1,3

Carbon–Carbon Bond Formation for the Synthesis of 5-Aryl-2-Substituted Furans Catalyzed by K3[Fe(CN)6]

An efficient method for the carbon–carbon bond formation at C-5 position of 2-substituted furans to provide a range of π-diverse 5-aryl-2-substituted furan derivatives in 58–80% yield has been reported. The method employs several advantages such as use of catalytic amount of K3[Fe(CN)6] under mild conditions and short reaction time with high yields. Also, a variety of anilines with a variety of functional groups can be employed for the synthesis of 5-aryl-2-substituted furans. Graphic Abstract: [Figure not available: see fulltext.]

2-furoylamide compound and preparation and application thereof

The invention discloses a 2-furancarboxamide compound and a preparation method and application thereof. The 2-furancarboxamide compound is obtained by reacting a compound as shown in a formula II with9H-pyridino[3,4-b]indole in the presence of an acid-bin

Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli β-glucuronidase inhibitors and their structure–inhibitory activity relationships

Gut microbial β-glucuronidases have the ability to deconjugate glucuronides of some drugs, thus have been considered as an important drug target to alleviate the drug metabolites-induced gastrointestinal toxicity. In this study, thiazolidin-2-cyanamide de

Novel S-Thiazol-2-yl-furan-2-carbothioate Derivatives as Potential T3SS Inhibitors against Xanthomonas oryzae on Rice

Bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv oryzae (Xoo) is considered as the most destructive disease of rice. The use of bactericides is among the most widely used traditional methods to control this destructive disease. The excessive an

Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists

The synthesis and biological evaluation as potential urotensin-II receptor antagonists of a series of 5-arylfuran-2-carboxamide derivatives 1, bearing a 4-(3-chloro-4-(piperidin-4-yloxy)benzyl)piperazin-1-yl group, are described. The results of a systemat

Synthesis and biological evaluation of 2,5-disubstituted furan derivatives as P-glycoprotein inhibitors for Doxorubicin resistance in MCF-7/ADR cell

Multidrug resistance (MDR) is a tendency in which cells become resistant to structurally and mechanistically unrelated drugs, which is mediated by P-glycoprotein (P-gp). It is one of the noteworthy problems in cancer therapy. As one of the most important

Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors

A series of 3,5-dimethylpyrazole derivatives containing 5-phenyl-2-furan moiety were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. Bioassay results showed that the title compounds exhibited considerable inhibitory activity agains

Tetrahydroquinoline and tetrahydroisoquinoline derivatives as potential selective PDE4B inhibitors

Tetrahydroquinoline and tetrahydroisoquinoline derivatives containing 2-phenyl-5-furan moiety were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. The bioassay results showed that title compounds showed good inhibitory activity aga

Synthesis and bioactivity of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan

A series of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan were synthesized. The antitumor tests showed that the title compounds exhibited promising activity against Bel-7402 and KB. The fungicidal tests showed that most of the title c