- Palladium-Catalyzed Thiomethylation via a Three-Component Cross-Coupling Strategy
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In this report, the combination of masked inorganic sulfur and dimethyl carbonate was designed to achieve thiomethylated cross coupling of aryl chlorides. Remarkably, this powerful strategy realized thiomethylation of nucleosides bearing unprotected ribose, chloride-containing pharmaceuticals with late-stage coupling, and herbicides possessing multiple heteroatoms and steric hindrance. Moreover, this protocol is practically amenable to multigram-scale synthesis with a lower catalysis loading and a higher yield.
- Wang, Ming,Qiao, Zongjun,Zhao, Jiaoyan,Jiang, Xuefeng
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supporting information
p. 6193 - 6197
(2018/09/25)
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- Methyl aryl thioether compound, and synthetic method and applications thereof
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The invention discloses a methyl aryl thioether compound represented by formula 2, and a synthetic method and applications thereof. According to the synthetic method, in a reaction solvent, an aryl halide or an aromatic halide, dimethyl carbonate, and potassium thioacetate are taken as reaction raw materials, reaction is carried out in the presence of metal palladium catalyst under the action of a ligand and an alkali so as to obtain the methyl aryl thioether compound. The reaction conditions of the synthetic method are mild; the raw materials are cheap and easily available; reaction operation is simple; yield is relatively high. The methyl aryl thioether compound can be used for providing skeleton structures for the synthesis of a plurality of natural products and medicines, and can be widely applied in industrialized large-scale production.
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Paragraph 0188; 0189; 0190
(2017/07/21)
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- Process for the preparation of 2,4-di(alkylamino)-6-alkylthio-s-triazines
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An improved process for the preparation of 2,4-di(alkylamino)-6-alkylthio-s-triazines wherein cyanuric chloride is reacted in successive steps with two appropriate alkylamines and an alkyl mercaptan is described where the improvement involves use of a single water-immiscible solvent and a phase transfer catalyst in the mercaptan addition step.
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- Agent for combating sea-water algae
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A sea-water algicidal composition containing a triazine of the group comprising 2-methylthio-4-cyclopropylamino-6-(α,β-dimethylpropylamino)-s-triazine (I); 2-methylthio-4-cyclopropylamino-6-t-butylamino-s-triazine (II); and 2-methylthio-4-ethylamino-6-(α,β-dimethylpropylamino)-s-triazine.
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