JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF
Provided herein are pyrrolotriazine compounds for treatment of JAK kinase, including JAK2 kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.
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Page/Page column 118-119
(2010/04/03)
Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists
The synthesis and biological testing of novel classes of potent melanin-concentrating hormone (MCH-R1) antagonists based on pyrazolopiperazinone and pyrrolopiperazinone scaffolds are described.
Meyers, Kenneth M.,Mendez-Andino, Jose,Colson, Anny-Odile,Hu, X. Eric,Wos, John A.,Mitchell, Maria C.,Hodge, Karen,Howard, Jeremy,Paris, Jennifer L.,Dowty, Martin E.,Obringer, Cindy M.,Reizes, Ofer
p. 657 - 661
(2007/10/03)
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