282089-49-0

Basic information

• Product Name: JTE 907
• Synonyms: JTE 907;N-(1,3-BENZODIOXOL-5-YLMETHYL)-1,2-DIHYDRO-7-METHOXY-2-OXO-8-(PENTYLOXY)-3-QUINOLINECARBOXAMIDE;N-(Benzo[d][1,3]dioxol-5-ylMethyl)-7-Methoxy-2-oxo-8-(pentyloxy)-1,2-dihydro-quinolin-3-carboxaMide;N-(benzo[d][1,3]dioxol-5-ylMethyl)-7-Methoxy-2-oxo-8-(pentyl;3-QuinolinecarboxaMide,N-(1,3-benzodioxol-5-ylMethyl)-1,2-dihydro-7-Methoxy-2-oxo-8-(pentyloxy)-
• CAS NO: 282089-49-0
• Molecular Formula: C24H26N2O6
• Molecular Weight: 438.47304
• Mol File: 282089-49-0.mol

Chemical Properties

• Boiling Point: 704.223 °C at 760 mmHg
• Flash Point: 379.701 °C
• Appearance: white to off-white/
• Density: 1.267 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: Store at RT
• Solubility: DMSO: ≥10mg/mL
• CAS DataBase Reference: JTE 907(CAS DataBase Reference)
• NIST Chemistry Reference: JTE 907(282089-49-0)
• EPA Substance Registry System: JTE 907(282089-49-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• RTECS: VB1150900
• Hazardous Substances Data: 282089-49-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
JTE 907 is used as a selective cannabinoid CB2 receptor inverse agonist for its anti-inflammatory properties. It has therapeutic potential in treating CB2Rs related inflammatory diseases due to its ability to inhibit carrageenin-induced edema in mouse paws and spontaneous scratching in a mouse model of chronic dermatitis.
Used in Research Applications:
JTE 907 is used as a potent and selective ligand for cannabinoid type 2 receptors (CB2Rs) in research settings, aiding in the study of CB2Rs related inflammatory diseases and the development of novel therapeutic strategies.
Used in Drug Development:
JTE 907 is utilized as a starting point for the development of new drugs targeting CB2 receptors, potentially leading to the creation of more effective treatments for various inflammatory conditions.

Biological Activity

Highly selective cannabinoid CB 2 receptor inverse agonist. Binds with high affinity to rat, mouse and human CB 2 receptors (K i values are 0.38, 1.55 and 35.9 nM respectively). Produces anti-inflammatory effects in vivo .

Biochem/physiol Actions

JTE-907 is a cannabinoid CB2 ligand (inverse agonist). CB2 cannabanoid receptors are expressed in periferal nerves and other non CNS tissues, but are not expressed in the brain. CB2 is believed to have a role in nociceptive pain, but additional functions pertaining to the immune system have yet to be determined. CB2 selective agonists and antagonists provide a necessary tool for functional analyses.

InChI:InChI=1/C24H26N2O6/c1-3-4-5-10-30-22-19(29-2)9-7-16-12-17(24(28)26-21(16)22)23(27)25-13-15-6-8-18-20(11-15)32-14-31-18/h6-9,11-12H,3-5,10,13-14H2,1-2H3,(H,25,27)(H,26,28)

Upstream product

• 2620-50-0 1,3-benzodioxol-5-ylmethyl amine 
• 219607-44-0 2-amino-4-methoxy-3-pentyloxybenzaldehyde 
• 194360-76-4 4-methoxy-2-nitro-3-pentyloxybenzaldehyde 
• 219607-46-2 7-methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxylic acid 
• 883229-00-3 7-methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxylic acid ethyl ester 
• 621-59-0 isovanillin 
• 6284-92-0 3-hydroxy-4-methoxy-2-nitrobenzaldehyde 

Relevant articles and documents

Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists

The highly CB2 selective cannabinoid receptor inverse agonist, 7-methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxylic acid N-benzo[1,3]dioxol-5-ylmethyl)amide (JTE-907; 9b), served as the lead compound for investigating the structure-activity relat

2-oxoquinoline compounds and medicinal uses thereof

A 2-oxoquinoline compound or its pharmaceutically acceptable salt of general formula [I]: ? (wherein each symbol in the formula is as determined in the description), and its pharmaceutical use. The compound [I] of the present invention and its pharmaceutically acceptable salts selectively act on cannabinoid receptors, particularly on peripheral type cannabinoid receptors, and have fewer side effects on the central nervous system, having great immunosuppressive action, anti-inflammatory action or antiallergic action. Therefore, these compounds are useful as cannabinoid receptors (particularly peripheral type cannabinoid receptors) modulator, immunosuppressants, anti-inflammatory agents, and antiallergic agents.