28276-08-6Relevant articles and documents
COMPLEXES OF IMIDAZOLE LIGANDS
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Page/Page column 82, (2012/01/05)
Metal imidazolate complexes are described where imidazoles ligands functionalized with bulky groups and their anionic counterpart, i.e., imidazolates are described. Compounds comprising one or more such polyalkylated imidazolate anions coordinated to a metal or more than one metal, selected from the group consisting of alkali metals, transition metals, lanthanide metals, actinide metals, main group metals, including the chalcogenides, are contemplated. Alternatively, multiple different imidazole anions, in addition to other different anions, can be coordinated to metals to make new complexes. The synthesis of novel compounds and their use to form thin metal containing films is also contemplated.
NOVEL PYRIMIDINE NUCLEOSIDE COMPOUND OR ITS SALT
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Page/Page column 21, (2008/06/13)
A novel pyrimidine nucleoside compound represented by the following formula (1) : (wherein one of X and Y represents a cyano group, and the other represents a hydrogen atom; one of R1 and R2 represents a hydrogen atom, a carbonyl group having a C1-C6 alkyl group which has been mono-substituted by an amino group, or a group represented by (R3) (R4) (R5) Si-, and the other represents a silyl group represented by (R6) (R7) (R8) Si-, or R1 and R2 together form a 6-membered cyclic group represented by -Si(R9)(R10)-; R3, R4, R5, R6, R7, and R8 each represent an alkyl group, a cyclic alkyl group, an aryl group, or an alkyl group which has been substituted by one or two aryl groups; and R9 and R10 each represent an alkyl group) or a salt thereof. The novel pyrimidine nucleoside compound exhibits excellent anti-tumor effect as compared with existing pyrimidine nucleoside compounds.
Absolute kinetic rate constants and activation energies for the formation of Grignard reagents
Beals, Bridget J.,Bello, Zainab I.,Cuddihy, Kathleen P.,Healy, Ethan M.,Koon-Church, Stephanie E.,Owens, Jane M.,Teerlinck, Cynthia E.,Bowyer, Walter J.
, p. 498 - 503 (2007/10/03)
This paper reports the first absolute rate constants for the formation of Grignard reagents from magnesium metal and organohalides. The theory that allows calculation of heterogeneous rate constants from the rate of growth of individual pits is described. By monitoring the reaction of individual reactive sites on the magnesium surface using photomicrography, it is possible to determine the rate of reaction and the active surface area; rate constants then are calculated from those data. Rate constants are on the order of 10-4 cm/s and vary relatively little between various organohalides. By measuring rate constants over a range of temperatures, Arrhenius parameters are determined for the reaction. The magnitudes of the enthalpic and entropic barriers are not consistent with electron transfer as the rate-limiting step. Rather, the data suggest that the rate-limiting step is reaction of the organohalide at the magnesium surface with partial insertion of a magnesium atom into the carbon-halide bond in the transition state.
Method for the preparation of a tert-hydrocarbyl silyl compound
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, (2008/06/13)
A tert-hydrocarbyl, e.g. tert-butyl, silyl compound can be synthesized easily according to the method of the invention in which a tert-hydrocarbylmagnesium halide as a Grignard reagent is reacted with a silane compound having at least one silicon-bonded hydrogen atom and at least one silicon-bonded halogen atom simultaneously in a molecule in a suitable organic solvent so that the halogen atom in the latter reactant is replaced with the tert-hydrocarbyl group in the former reactant to give the desired tert-hydrocarbyl silyl compound in a high yield without the safety problem in the conventional method using a tert-alkyl lithium as the reactant.
