283159-92-2

Basic information

• Product Name: METHYL (3R)-3-AMINO-3-(4-CHLOROPHENYL)PROPANOATE
• Synonyms: METHYL (3R)-3-AMINO-3-(4-CHLOROPHENYL)PROPANOATE
• CAS NO: 283159-92-2
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.66078
• Mol File: 283159-92-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL (3R)-3-AMINO-3-(4-CHLOROPHENYL)PROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (3R)-3-AMINO-3-(4-CHLOROPHENYL)PROPANOATE(283159-92-2)
• EPA Substance Registry System: METHYL (3R)-3-AMINO-3-(4-CHLOROPHENYL)PROPANOATE(283159-92-2)

Safety Data

• Hazardous Substances Data: 283159-92-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
METHYL (3R)-3-AMINO-3-(4-CHLOROPHENYL)PROPANOATE is used as an intermediate in the synthesis of various drugs and pharmaceuticals. Its unique structure, featuring an amino group and a chlorophenyl group, allows it to be a key component in the development of new drug candidates.
Used in Research and Development:
In the field of research and development, METHYL (3R)-3-AMINO-3-(4-CHLOROPHENYL)PROPANOATE serves as a valuable compound for the exploration and creation of novel drug candidates. Its properties make it a promising starting point for the design and synthesis of new therapeutic agents.
Used in Organic Chemistry and Chemical Synthesis:
METHYL (3R)-3-AMINO-3-(4-CHLOROPHENYL)PROPANOATE may also have potential applications in the broader field of organic chemistry and chemical synthesis. Its structural features can be utilized in various chemical reactions and processes, contributing to the advancement of chemical knowledge and the development of new compounds and materials.

Upstream product

• 1143534-42-2 (R)-methyl 3-(tert-butoxycarbonyl)-3-(4-chlorophenyl)propanoate 

Downstream Products

• 1143534-45-5 (R)-methyl 3-(4-(tert-butoxycarbonylamino)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)-3-(4-chlorophenyl)propanoate 

Relevant articles and documents

Stereoselective chemoenzymatic preparation of β-amino esters: Molecular modelling considerations in lipase-mediated processes and application to the synthesis of (S)-dapoxetine

A wide range of optically active 3-amino-3-arylpropanoic acid derivatives have been prepared by means of a stereoselective chemoenzymatic route. The key step is the kinetic resolution of the corresponding β-amino esters. Although the enzymatic acylations of the amino group with ethyl methoxyacetate showed synthetically useful enantioselectivities, the hydrolyses of the ester group catalyzed by lipase from Pseudomonas cepacia have been identified as the optimal processes concerning both activity and enantioselectivity. The enantiopreference of this lipase in these reactions has been explained, at the molecular level, by using a fragment-based approach in which the most favoured binding site for a phenyl ring and the most stable conformation of the 3-aminopropanoate core nicely match the (S)-configuration of the major products. The conversion and enantioselectivity values of the enzymatic reactions have been compared in order to understand the influence of the different substitution patterns present in the phenyl ring. This chemoenzymatic route has been successfully applied to the preparation of a valuable intermediate in the synthesis of (S)-dapoxetine, which has been chemically synthesised in excellent optical purity.

PYRROLO [2,3-D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS

The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I)