284027-37-8

Basic information

• Product Name: 6-TRIFLUOROMETHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
• Synonyms: 6-TRIFLUOROMETHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE;Isoquinoline, 1,2,3,4-tetrahydro-6-(trifluoroMethyl)-
• CAS NO: 284027-37-8
• Molecular Formula: C₁₀H₁₀F₃N
• Molecular Weight: 201.1883096
• Mol File: 284027-37-8.mol

Chemical Properties

• Boiling Point: 228.9°C at 760 mmHg
• Flash Point: 92.2°C
• Appearance: /
• Density: 1.213g/cm³
• Vapor Pressure: 0.0716mmHg at 25°C
• Refractive Index: 1.475
• Storage Temp.: 2-8°C
• PKA: 8.68±0.20(Predicted)
• CAS DataBase Reference: 6-TRIFLUOROMETHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-TRIFLUOROMETHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(284027-37-8)
• EPA Substance Registry System: 6-TRIFLUOROMETHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(284027-37-8)

Safety Data

• Hazardous Substances Data: 284027-37-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline is used as a pharmaceutical compound for its potential applications in the development of new drugs. Its unique structure and properties contribute to its interest in medicinal chemistry, where it may be utilized to target specific biological pathways or receptors.
Used in Organic Synthesis:
In the field of organic synthesis, 6-Trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline serves as a building block for the creation of other related compounds. Its presence in various synthetic pathways allows for the development of a range of chemical entities that can be further explored for their potential applications in different industries.
Used in Medicinal Chemistry Research:
6-Trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline is used as a subject of interest in research and development within medicinal chemistry. Its unique attributes make it a valuable component for exploring new therapeutic agents and understanding the mechanisms of action in various diseases and conditions.

InChI:InChI=1/C10H10F3N/c11-10(12,13)9-2-1-8-6-14-4-3-7(8)5-9/h1-2,5,14H,3-4,6H2

Upstream product

• 181514-46-5 2,2,2-trifluoro-1-(6-trifluoromethyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethanone 
• 1194375-62-6 6-(trifluoromethyl)isoquinoline 
• 106778-43-2 isoquinoline-6-carboxylic acid 

Relevant articles and documents

Deoxofluorination of (Hetero)aromatic Acids

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

Substituted phenyl methanones

The present invention relates to compounds of general formula IA or IB wherein X1 and X2 are each independently N or C—R″ and R1, R2,R3, R4, R5, and R6 are as defined

TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to compounds of the formula I: I(wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.