284465-78-7Relevant articles and documents
Synthesis and anti-inflammatory activity of 2,3-diaryl-4(3H)-quinazolinones
Yadav,Shirude,Parmar,Balaraman,Giridhar
, p. 1038 - 1045 (2008/09/16)
2,3-Diaryl-4(3H)-quinazolinones containing various substituents on diaryl rings have been synthesized and evaluated for their cyclooxygenase-2 inhibitory activity by the colorimetric COX (ovine) inhibitor screening assay and anti-inflammatory activity by the carrageenan-induced rat paw edema assay. 2-(4-Nitrophenyl)-3-(4-tolyl)-4(3H)-quinazolinone showed a maximum COX-2 inhibition of 27.72% at 22 μM concentration in the present series and exhibited a mild anti-inflammatory activity at a dose of 50 mg/kg in carrageenan-induced rat paw edema assay.