284490-13-7

Basic information

• Product Name: 4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride
• Synonyms: 4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride;Forodesine hydrochloride;BCX-1777;Immucillin-H hydrochloride;Forodesine HCl
• CAS NO: 284490-13-7
• Molecular Formula: C11H15ClN4O4
• Molecular Weight: 302.7142
• Mol File: 284490-13-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride(284490-13-7)
• EPA Substance Registry System: 4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride(284490-13-7)

Safety Data

• Hazardous Substances Data: 284490-13-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride is used as a potential therapeutic agent for the treatment of T-Cell malignancies such as acute lymphoblastic leukemia (ALL) and cutaneous T-cell lymphoma. Its unique molecular structure allows it to target specific biological pathways involved in these diseases, offering a new approach to their treatment.
Used in Enzyme Inhibition:
In the field of biochemistry and pharmacology, 4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride is used as a potent inhibitor of bovine purine nucleoside phosphorylase (PNP). It is specifically designed as a transition state mimic, with an inhibition constant (Ki) of 23-pM, indicating its high affinity and specificity for the target enzyme. This property makes it a valuable tool for studying the function and regulation of PNP, as well as for the development of new therapeutic strategies targeting this enzyme.
Used in Drug Design and Development:
The unique structural features of 4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride also make it a promising candidate for drug design and development. Its ability to interact with various biological targets can be exploited to develop new drugs with improved efficacy and selectivity. Researchers can use this compound as a starting point for the design of novel therapeutic agents targeting a wide range of diseases and conditions.