28465-95-4

Basic information

• Product Name: 4-Amino-1-(2-pyridyl)pyrazole
• Synonyms: 4-Amino-1-(2-pyridyl)pyrazole;1-(2-Pyridyl)-1H-pyrazol-4-amine;2-(4-Amino-1H-pyrazol-1-yl)pyridine;1-(pyridin-2-yl)-1H-pyrazol-4-amine
• CAS NO: 28465-95-4
• Molecular Formula: C8H8 N4
• Molecular Weight: 160.18
• Mol File: 28465-95-4.mol

Chemical Properties

• Melting Point: 73-76 °C
• Boiling Point: 338.2°Cat760mmHg
• Flash Point: 158.4°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 9.96E-05mmHg at 25°C
• Refractive Index: 1.689
• PKA: 2.90±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-1-(2-pyridyl)pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-1-(2-pyridyl)pyrazole(28465-95-4)
• EPA Substance Registry System: 4-Amino-1-(2-pyridyl)pyrazole(28465-95-4)

Safety Data

• Hazardous Substances Data: 28465-95-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8N4/c9-7-5-11-12(6-7)8-3-1-2-4-10-8/h1-6H,9H2

Upstream product

• 25700-11-2 2-(pyrazol-1-yl)pyridine 
• 109-09-1 2-chloropyridine 
• 171193-35-4 ethyl 1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate 
• 77556-50-4 2-(pyrazol-1'-yl)pyridine-4'-carboxylic acid 
• 1316122-62-9 tert-butyl [1-(pyridin-2-yl)-1-pyrazol-4-yl]carbamate 
• 5029-67-4 2-iodopyridine 
• 28469-29-6 2-(4-nitro-1H-pyrazol-1-yl)pyridine 

Relevant articles and documents

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

Substituted heteroaryl compounds and composition thereof, and applicaitons of compounds and composition

The invention provides substituted heteroaryl compounds and a composition thereof, and applicaitons of the compounds and the composition. The compounds are compounds represented by the formula (I) or the formula (II) or stereoisomers, tautomers, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts or prodrugs of the compounds represented by the formula (I) or the formula (II). The invention also provides the pharmaceutical composition comprising the compounds; the compounds and the pharmaceutical composition can adjust the activity of protein kinase, and are used for prevention, processing, treatment and remission of diseases or disorders mediated by the protein kinase.

NITROGEN-CONTAINING HETEROARYL DERIVATIVES

The invention is concerned with novel nitrogen-containing heteroaryl derivatives of formula (I) wherein R1, R2, R3, R4, R5, A1, A2, and Y are as defined in the description and in

NITROGEN-CONTAINING HETEROARYL DERIVATIVES

The invention is concerned with novel nitrogen-containing heteroaryl derivatives of formula (I) wherein R1, R2, R3, R4, R5, A1, A2, and Y are as defined in the description and in

Hetarylyrazoles. II. Reactions of Pyrazol-1'-ylpyridines

Pyrazol-1'-ylpyridines undergo electrophilic substitution reactions (bromination, chlorination and nitration) preferentially in the pyrazole ring.There is some evidence of the mutual influence of the pyrazole and the pyridine ring on the reactivity of the