- Aryliodoazide synthons: A different approach for diversified synthesis of 2-aminothiazole, 1,3-thiazole, and 1,3-selenazole scaffolds
-
Several straightforward and practical processes have been established for the construction of 2-aminothiazoles, 1,3-thiazoles and 1,3-selenazoles from aryliodoazides. These strategies successfully proceed with a wide spectrum of substituted thioamides and its derivatives producing the resulting five-membered heterocycles obtained in satisfactory yields. The unique features of these protocols are operational simplicity and highly functional group tolerance, which make them convenient and practical routes for the preparation of various libraries of 2-aminothiazoles, 1,3-thiazoles, and 1,3-selenazoles.
- Majnooni, Sahar,Duffield, Joseph,Price, Jessica,Khosropour, Ahmad Reza,Zali-Boeini, Hassan,Beyzavi, M. Hassan
-
supporting information
p. 516 - 521
(2019/08/01)
-
- Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells
-
This Letter presents the synthesis and biological evaluation of a collection of 2-aminothiazoles as a novel class of compounds with the capability to reduce the production of PGE2 in HCA-7 human adenocarcinoma cells. A total of 36 analogs were
- Smith, Breland,Chang, Hui-Hua,Medda, Federico,Gokhale, Vijay,Dietrich, Justin,Davis, Angela,Meuillet, Emmanuelle J.,Hulme, Christopher
-
experimental part
p. 3567 - 3570
(2012/07/03)
-