28636-21-7

Basic information

• Product Name: monensin methyl ester
• Synonyms: 1,6-Dioxaspiro[4.5]decane-7-butyricacid,2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-b-methoxy-a,g,2,8-tetramethyl-, methyl ester (8CI);1,6-Dioxaspiro[4.5]decane, monensin deriv.; Methyl monensin; Monensin A methylester
• CAS NO: 28636-21-7
• Molecular Formula: C₃₇H₆₄O₁₁
• Molecular Weight: 684.902
• Mol File: 28636-21-7.mol

Chemical Properties

• Boiling Point: 752.1±60.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.49±0.70(Predicted)
• BRN: 3641733
• CAS DataBase Reference: monensin methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: monensin methyl ester(28636-21-7)
• EPA Substance Registry System: monensin methyl ester(28636-21-7)

Safety Data

• Hazard Codes: T
• Statements: 24/25
• Safety Statements: 36/37-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 28636-21-7(Hazardous Substances Data)

Usage

Uses

1. Used in Pharmaceutical Industry:
Monensin methyl ester is used as a pharmaceutical compound for its ionophore properties, which allow it to complex with divalent cations. This characteristic can be utilized in the development of drugs targeting specific ion channels or transport mechanisms in the body.
2. Used in Veterinary Medicine:
In the veterinary medicine industry, monensin methyl ester is used as an additive in animal feed to improve the efficiency of nutrient utilization and promote overall health in livestock. Its ionophore properties help in the absorption of essential minerals and prevent the growth of harmful bacteria in the animal's digestive system.
3. Used in Research and Development:
Monensin methyl ester is used as a research tool for studying the interactions between divalent cations and various biological systems. Its ability to form complexes with these cations makes it a valuable compound for understanding the role of these ions in cellular processes and developing new therapeutic strategies.
4. Used in Analytical Chemistry:
Monensin methyl ester can be employed as an analytical reagent in the field of chemistry, particularly in the development of new methods for the detection and quantification of divalent cations in various samples. Its complexation properties can be exploited to create selective and sensitive assays for these ions.

Upstream product

• 17090-79-8 monensin 
• 74-88-4 methyl iodide 

Downstream Products

• 116278-48-9 C₄₄H₆₈O₁₁ 
• 22373-78-0 monensin sodium salt 
• 116278-49-0 C₄₄H₆₆O₁₁ 

Relevant articles and documents

Enhancement of ricin toxin A chain immunotoxin activity: Synthesis, ionophoretic ability, and in vitro activity of monensin derivatives

Site-selective toxin delivery was achieved by coupling monoclonal antibody to the A chain subunit of ricin (RTA-IT). The cell-killing potency of RTA-IT can be drastically increased in vitro by using ionophores such as monensin. To reduce the intrinsic tox

Reaction of monensin silver salt with methyl iodide: Smooth alkylation of a tightly hydrogen-bonded carboxylate

Despite its structural similarity to the sparingly reactive sodium salt of monensin, the silver salt of monensin was smoothly alkylated with methyl iodide on the carboxyl group to give the methyl ester of monensin.

Design and synthesis of lithium ionophores for an ion-selective electrode by chemical modification of natural carboxylic polyether antibiotic monensin

Ion-selective electrodes were prepared with 12 kinds of monensin derivatives obtained by chemical modification of natural antibiotic monensin, and the relationship between the chemical structures of the derivatives and the ion selectivities of those electrodes was investigated for designing Li+-selective ionophores. Lactonization of monensin and subsequent acylation of its tertiary hydroxyl group are effective for obtaining highly Li+-selective ionophores. Of all the monensin derivatives synthesized, macrocyclic monensin monoisobutyrate proved to have the highest Li+ selectivity. The selectivity coefficient of Li+ to Na+ (log KLINapot) was -1.8 in the poly(vinyl chloride) (PVC) matrix membrane electrode, which was prepared by using the macrocyclic monensin derivative and dibenzyl ether (DBE) as the membrane solvent.