287114-32-3

Basic information

• Product Name: 1-(2-Pyridinyl)hexahydro-1H-1,4-diazepine
• Synonyms: 1-PYRIDINE-2-YL-[1,4]-DIAZEPANE;1-(2-Pyridinyl)hexahydro-1H-1,4-diazepine;1-(2-Pyridyl)homopiperazine
• CAS NO: 287114-32-3
• Molecular Formula: C₁₀H₁₅N₃
• Molecular Weight: 177.25
• Product Categories: pharmacetical
• Mol File: 287114-32-3.mol

Chemical Properties

• Boiling Point: 104℃/0.4mm
• Flash Point: 150.036 °C
• Appearance: /
• Density: 1.05 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: 2-8°C
• PKA: 10.34±0.20(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 1-(2-Pyridinyl)hexahydro-1H-1,4-diazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Pyridinyl)hexahydro-1H-1,4-diazepine(287114-32-3)
• EPA Substance Registry System: 1-(2-Pyridinyl)hexahydro-1H-1,4-diazepine(287114-32-3)

Safety Data

• HazardClass: 8
• Hazardous Substances Data: 287114-32-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Pyridinyl)hexahydro-1H-1,4-diazepine is used as a biologically active compound for its potential to combat certain pathogens, making it a candidate for development into new pharmaceutical agents.
Used in Organic Synthesis:
As a versatile intermediate, 1-(2-Pyridinyl)hexahydro-1H-1,4-diazepine is utilized in organic synthesis to construct a range of chemical entities, contributing to the discovery and development of novel compounds with potential applications in various fields.
Used in Drug Discovery Research:
1-(2-Pyridinyl)hexahydro-1H-1,4-diazepine is employed as a key component in drug discovery research, where its unique structure aids in the exploration of new therapeutic agents and the enhancement of existing ones.

InChI:InChI=1/C10H15N3/c1-2-6-12-10(4-1)13-8-3-5-11-7-9-13/h1-2,4,6,11H,3,5,7-9H2

Upstream product

• 505-66-8 1,4-Diazacycloheptane 
• 109-04-6 2-bromo-pyridine 
• 112275-50-0 tert-butyl 1,4-diazepine-1-carboxylate 
• 632334-60-2 tert-butyl 4-(2-pyridyl)-1,4-diazepane-1-carboxylate 
• 13716-12-6 tri-tert-butyl phosphine 
• 109-09-1 2-chloropyridine 

Downstream Products

• 112275-50-0 tert-butyl 1,4-diazepine-1-carboxylate 
• 1373271-02-3 1-{1-[(2-chlorophenyl)methyl]piperidin-4-yl}-4-(pyridin-2-yl)-1,4-diazepane 
• 1609534-94-2 1,1-diethyl-4-(2-pyridyl)-homopiperazinium tosylate 

Relevant articles and documents

METHOD FOR USE OF HOMOPIPERAZINIUM COMPOUNDS IN THE TREATMENT OF CANCER

The present disclosure relates to a method for treating cancer comprising administering to a patient in need thereof an effective amount of a compound having the formula: (Formula (I)) wherein R1, R2, Ya, Xa, and J- are as defined herein.

Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents

A cell-based assay was performed for the discovery of novel bone anabolic agents. Alkaline phosphatase (ALPase) activity of ST2 cells was utilized as an indicator of osteoblastic differentiation, and thienopyridine derivative 1 was identified as a hit compound. 3-Aminothieno[2,3-b]pyridine-2-carboxamide was confirmed to be a necessary core structure for the enhancement of ALPase activity, and then optimization of the C4-substituent on the thienopyridine ring was carried out. Introduction of cyclic amino groups to the C4-position of the thienopyridine ring improved the activity. Especially, N-phenyl-homopiperazine derivatives were found to be strong enhancers of ALPase among this new series. Furthermore, 3-amino-4-(4-phenyl-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2- carboxamide (15k) was orally administered to ovariectomized (OVX) rats over 6 weeks for evaluating the effects on areal bone mineral density (aBMD), and statistically significant improvements in aBMD were observed from the dosage of 10 mg/kg/day.

CXCR4 Receptor Antagonists

Disclosed are compounds that are antagonists of the CXCR4 receptor.

TRIAZOLE DERIVATIVES HAVING ANTIFUNGAL ACTIVITY, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

A triazole derivative of formula 1 or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof is superior to the conventional antifungal drugs in antifungal activity against a wide spectrum of pathogenic fungi, and has advantageously low toxicity.

THIENOPYRIDINE DERIVATIVES

The present invention provides a compound promoting osteogenesis. The present invention provides a compound having the following general formula (I) wherein R 1 is H or alkyl, R 2 is R a S-, R a O-, R a NH-, R a (R b )N- or cyclic amino, and R a and R b are alkyl which may be substituted, cycloalkyl which may be substituted, or the like, or a pharmacologically acceptable salt thereof.

Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D and B, are as described in the specification.

Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use

The invention relates to compounds of formula: and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards the arginine-vasopressin V1b receptors and/or for the ocytocin receptors and, furthermore, for certain compounds, affinity for the V1a receptors. The invention also relates to the process for preparing them, to the intermediate compounds of formula (IV) that are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

FUSED BICYCLIC AROMATIC COMPOUNDS THAT ARE USEFUL IN TREATING SEXUAL DYSFUNCTION

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

MEDICINAL COMPOSITION

The present invention is composed of a pharmaceutical composition for the therapy of nephritis which comprises an amide derivative represented by the following formula [1] or pharmaceutically acceptable salt thereof, as an active ingredient: ???wherein R1 and R2 may be the same or different and each is hydrogen, alkyl which may be substituted, acyl, aryl which may be substituted, or an aromatic heterocyclic group which may be substituted; R3, R4, R5 and R6 may be the same or different and each is hydrogen, halogen, hydroxy, amino which may be substituted, alkyl which may be substituted, alkoxy or nitro and the like; and R7 represents cyclic amino which may be substituted or azabicycloalkylamino which may be substituted. The pharmaceutical composition of the invention is useful for the therapy of nephritis.