- Direct catalytic synthesis of unprotected 2-amino-1-phenylethanols from alkenes by using iron(II) phthalocyanine
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Aryl-substituted amino alcohols are privileged scaffolds in medicinal chemistry and natural products. Herein, we report that an exceptionally simple and inexpensive FeII complex efficiently catalyzes the direct transformation of simple alkenes into unprotected amino alcohols in good yield and perfect regioselectivity. This new catalytic method was applied in the expedient synthesis of bioactive molecules and could be extended to aminoetherification.
- Legnani, Luca,Morandi, Bill
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supporting information
p. 2248 - 2251
(2016/02/18)
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- A facile approach to α,β-unsaturated lactams by ring-closing metathesis
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[MediaObject not available: see fulltext.]A facile and efficient strategy for the synthesis of α,β-unsaturated lactams through ring-closing metathesis of easily prepared diene amides is being reported here. Reaction conditions were optimized for metathetic cyclization of diene amides to obtain five- to sevenmembered unsubstituted and β-substituted α,β-unsaturated lactams in good to excellent yield.
- Gondal, Humaira Yasmeen,Buisson, Didier
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p. 183 - 191
(2016/07/28)
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- Total synthesis of pulchellalactam via an RCM strategy
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Total synthesis of (Z) pulchellalactam, a CD protein tyrosine phosphatase inhibitor, from commercially available methallyl chloride employing ring-closure metathesis (RCM) as a key step is described. Copyright Taylor & Francis Group, LLC.
- Chavan, Subhash P.,Pathak, Ashok B.,Dhawane, Abasaheb N.,Kalkote
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p. 1503 - 1510
(2008/02/03)
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- SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS
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The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed
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- Preparation of secondary aminoisobutylalkoxysilanes
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A highly efficient method is provided for preparing secondary aminoisobutylalkoxysilanes by reacting hydridoalkoxysilanes with secondary methallylamines in the presence of a hydrosilation catalyst.
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- Ring closing metathesis of phenyl-substituted dienes
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A series of phenyl-substituted heterodienes 2a-f and 6 was prepared and subjected to ring closing metathesis (RCM) to give differently phenyl- substituted dihydropyrroles and dihydrofuran.
- Bujard,Briot,Gouverneur,Mioskowski
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p. 8785 - 8788
(2007/10/03)
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- Synthesis of primary amines using potassium 1,1,3,3-tetramethyldisilazide as aminating agent of alkyl halides
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A one-pot synthesis of various primary amines is described. Potassium 1,1,3,3-tetramethyldisilazide, prepared from 1,1,3,3-tetramethyldisilazane and potassium hydride, reacts with alkyl bromides, iodides, tosylates, benzylic chlorides, and allylic chlorides to give the corresponding N,N-bis(dimethylsilyl)amines in high yields. Subsequent deprotection of the dimethylsilyl group was performed under mildly acidic conditions to afford primary amines. This method was also applied to the preparation of aminomethylated cross-linked polystyrene.
- Itsuno,Koizumi,Okumura,Ito
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p. 150 - 152
(2007/10/02)
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- Pharmaceutical compositions and methods of inhibiting gastric acid secretion
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Pharmaceutical compositions and methods of inhibiting gastric acid secretion by administering N-alkenyl and N-alkynyl thioamides.
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