288154-18-7Relevant articles and documents
Spiro compound
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, (2020/07/06)
The invention discloses a spiro compound, application thereof and a pharmaceutical composition containing the spiro compound. The structure of the compound is shown as a formula I, and the compound has a good inhibition effect on RET kinase.
RET inhibitor
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, (2020/06/20)
The invention discloses a compound, application thereof and a pharmaceutical composition containing the compound. The structure of the compound is shown as a formula I, and the compound has a good inhibition effect on RET kinase.
SUBSTITUTED HETEROCYCLIC INHIBITORS OF PTPN11
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Page/Page column 0341-0342, (2019/11/19)
The present invention relates to compounds which may be useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their applica
HETEROCYCLIC INHIBITORS OF PTPN11
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Paragraph 0442; 0443, (2018/01/04)
The present invention relates to compounds which may be useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their applica
ACETYL CoA CARBOXYLASE INHIBITORS
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Page/Page column 51, (2009/10/17)
The present invention relates to acetyl coenzyme-A carboxylase (""ACC"") inhibiting compounds of the formula wherein the variables are as defined herein. In particular, the present invention relates to ACC1 and/or ACC2 inhibitors, compositions of matter,
CGRP RECEPTOR ANTAGONISTS
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Page/Page column 61, (2010/11/08)
The present invention is directed to compounds of Formula I: Formula I: I and Formula II: (where variables R1, R2, R3, R4, A, B, J, Q, T, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
CGRP RECEPTOR ANTAGONISTS
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Page/Page column 98, (2010/11/08)
Compounds of Formula (I): and Formula (II): (where variables R2, R4, A, B, D, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
A rational approach to the design and synthesis of a new bradykinin B1 receptor antagonist
Bedos, Philippe,Amblard, Muriel,Subra, Gilles,Dodey, Pierre,Luccarini, Jean-Michel,Paquet, Jean-Luc,Pruneau, Didier,Aumelas, André,Martinez, Jean
, p. 2387 - 2394 (2007/10/03)
We have previously synthesized a potent and selective B1 bradykinin receptor antagonist, JMV1645 (H-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH), containing a dipeptide mimetic ((3S)-amino-5-carbonylmethyl-2,3-dihydro-1,5- benzothiazepin-4(5H)-one (D-B