A new route to 4-ethynyl-N-hydroxy-2-imidazolidinones via oxime addition
A rapid route was developed to afford ethynyl-substituted imidazole derivatives which served as key compounds for arylalkynyl-coupling reactions. Addition of mono-silylated acetylene to O-protected oximes was carried out in the absence of Lewis acids, directly affording the title compounds 3a-c in a one-pot reaction. Limitations and dependence of the feasibility on N1- substituents are discussed. (C) 2000 Elsevier Science Ltd.
Ullrich, Thomas,Sulek, Peter,Binder, Dieter,Pyerin, Michael
p. 3697 - 3701
(2007/10/03)
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