Iridium-catalyzed direct asymmetric vinylogous allylic alkylation
The catalytic asymmetric vinylogous allylic alkylation of α,β-unsaturated lactones (including coumarins) was achieved with excellent regio- and enantioselectivity. Transformations of the product were carried out by means of the versatile terminal olefin and lactone moieties. The synthetic application of the present methodology was showcased by the asymmetric synthesis of an advanced synthetic Merck intermediate toward a new drug candidate.
Shi, Chang-Yun,Xiao, Jun-Zhao,Yin, Liang
supporting information
p. 11957 - 11960
(2018/11/02)
An efficient one-pot synthesis of coumarins mediated by propylphosphonic anhydride (T3P) via the Perkin condensation
An efficient one-pot synthesis of coumarins mediated by T3P, a mild and low toxic peptide coupling agent, via the Perkin condensation has been demonstrated.
Augustine, John Kallikat,Bombrun, Agnes,Ramappa, Balakrishna,Boodappa, Chandrakantha
experimental part
p. 4422 - 4425
(2012/09/25)
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