Staudinger ligation: a peptide from a thioester and azide.
[reaction: see text] The technique of native chemical ligation enables the total chemical synthesis of proteins. This method is limited, however, by an absolute requirement for a cysteine residue at the ligation juncture. Here, this restriction is overcome with a new chemical ligation method in which a phosphinobenzenethiol is used to link a thioester and azide. The product is an amide with no residual atoms.
Nilsson,Kiessling,Raines
p. 1939 - 1941
(2007/10/03)
More Articles about upstream products of 289038-92-2